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    Zwint ZW10 interactor [ Mus musculus (house mouse) ]

    Gene ID: 52696, updated on 21-Dec-2024

    Summary

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    Official Symbol
    Zwintprovided by MGI
    Official Full Name
    ZW10 interactorprovided by MGI
    Primary source
    MGI:MGI:1289227
    See related
    Ensembl:ENSMUSG00000019923 AllianceGenome:MGI:1289227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zwint-1; D10Ertd749e; 2010007E07Rik; 2600001N01Rik
    Summary
    Involved in homologous chromosome orientation in meiotic metaphase I and regulation of meiosis I spindle assembly checkpoint. Located in kinetochore. Is expressed in several structures, including early conceptus; heart valve; nervous system; oocyte; and retina. Orthologous to human ZWINT (ZW10 interacting kinetochore protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 121.8), cerebellum adult (RPKM 118.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zwint in Genome Data Viewer
    Location:
    10 B5.3; 10 37.15 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (72490678..72510796)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (72654846..72674964)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24984 Neighboring gene STARR-seq mESC enhancer starr_27125 Neighboring gene STARR-positive B cell enhancer ABC_E1803 Neighboring gene predicted gene, 34659 Neighboring gene STARR-seq mESC enhancer starr_27126 Neighboring gene RIKEN cDNA A330049N07 gene Neighboring gene predicted gene, 34776

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis. Woo Seo D, et al. Sci Rep, 2015 Oct 21. PMID 26486467, Free PMC Article
    2. A unique residue in rab3c determines the interaction with novel binding protein Zwint-1. van Vlijmen T, et al. FEBS Lett, 2008 Aug 20. PMID 18625232
    3. A two-hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25-interacting protein, SIP30. Gentil BJ, et al. J Neurochem, 2014 Dec. PMID 25113441
    4. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
    5. PEG3 control on the mammalian MSL complex. Ye A, et al. PLoS One, 2017. PMID 28609438, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of localization in cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homologous chromosome orientation in meiotic metaphase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of meiosis I spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Knl1/Spc105 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Knl1/Spc105 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    outer kinetochore KNL1 complex subunit ZWINT
    Names
    ZW10-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293683.1 → NP_001280612.1  outer kinetochore KNL1 complex subunit ZWINT

      See identical proteins and their annotated locations for NP_001280612.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK075977, BC034870, BY240779
      Consensus CDS
      CCDS23920.1
      UniProtKB/Swiss-Prot
      Q3UYT8, Q91VI4, Q9CQU5, Q9D0W9
      Related
      ENSMUSP00000020081.5, ENSMUST00000020081.11
      Conserved Domains (2) summary
      pfam15556
      Location:35 → 236
      Zwint; ZW10 interactor
      cl19764
      Location:126 → 215
      COG6; Conserved oligomeric complex COG6

    2. NM_001293684.1 → NP_001280613.1  outer kinetochore KNL1 complex subunit ZWINT

      See identical proteins and their annotated locations for NP_001280613.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC153870, AK008144, AK134380, BY240779
      Consensus CDS
      CCDS23920.1
      UniProtKB/Swiss-Prot
      Q3UYT8, Q91VI4, Q9CQU5, Q9D0W9
      Related
      ENSMUSP00000124429.2, ENSMUST00000160337.2
      Conserved Domains (2) summary
      pfam15556
      Location:35 → 236
      Zwint; ZW10 interactor
      cl19764
      Location:126 → 215
      COG6; Conserved oligomeric complex COG6

    3. NM_025635.4 → NP_079911.1  outer kinetochore KNL1 complex subunit ZWINT

      See identical proteins and their annotated locations for NP_079911.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC153870, AK134380, BY240779
      Consensus CDS
      CCDS23920.1
      UniProtKB/Swiss-Prot
      Q3UYT8, Q91VI4, Q9CQU5, Q9D0W9
      Related
      ENSMUSP00000101071.2, ENSMUST00000105431.8
      Conserved Domains (2) summary
      pfam15556
      Location:35 → 236
      Zwint; ZW10 interactor
      cl19764
      Location:126 → 215
      COG6; Conserved oligomeric complex COG6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      72490678..72510796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQU5.1 GenPept UniProtKB/Swiss-Prot:Q9CQU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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