Gpr21 G protein-coupled receptor 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr21provided by MGI
Official Full Name: G protein-coupled receptor 21provided by MGI
Primary source: MGI:MGI:2441890
See related: Ensembl:ENSMUSG00000053164 AllianceGenome:MGI:2441890
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C230004C13Rik
Summary: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within glucose homeostasis; negative regulation of insulin receptor signaling pathway; and regulation of growth. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; cerebral cortex marginal layer; cerebral cortex subventricular zone; and cortical plate. Orthologous to human GPR21 (G protein-coupled receptor 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 2.9), CNS E18 (RPKM 2.9) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 24.19 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (37406638..37409293)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (37516626..37519281)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.
Title: Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.
GPR21 is up-regulated in type 2 diabetes model.
Title: Regulating the effects of GPR21, a novel target for type 2 diabetes.
GPR21 has a critical function in coordinating macrophage proinflammatory activity in the context of obesity-induced insulin resistance
Title: G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.
these findings suggest that GPR21 may play an important role in regulating body weight and glucose metabolism.
Title: G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable G-protein coupled receptor 21

Names: G protein-coupled receptor GPR21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177383.4 → NP_796357.1 probable G-protein coupled receptor 21

See identical proteins and their annotated locations for NP_796357.1

Status: PROVISIONAL

Source sequence(s)

AK048682

Consensus CDS

CCDS16004.1

UniProtKB/Swiss-Prot

Q80T46, Q8BX79

Related

ENSMUSP00000066449.7, ENSMUST00000065441.7

Conserved Domains (2) summary

pfam00001
Location:45 → 304

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 216

7tm_4; Olfactory receptor