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    Id2 inhibitor of DNA binding 2 [ Mus musculus (house mouse) ]

    Gene ID: 15902, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Id2provided by MGI
    Official Full Name
    inhibitor of DNA binding 2provided by MGI
    Primary source
    MGI:MGI:96397
    See related
    Ensembl:ENSMUSG00000020644 AllianceGenome:MGI:96397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Idb2; bHLHb26
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription regulator inhibitor activity. Involved in several processes, including digestive tract morphogenesis; mammary gland epithelium development; and regulation of gene expression. Acts upstream of with a negative effect on regulation of gene expression; regulation of neural precursor cell proliferation; and regulation of neuron differentiation. Acts upstream of or within several processes, including hemopoiesis; nervous system development; and regulation of cell development. Located in cytoplasm; euchromatin; and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Orthologous to human ID2 (inhibitor of DNA binding 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 169.1), adrenal adult (RPKM 168.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Id2 in Genome Data Viewer
    Location:
    12 A1.3; 12 8.57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (25143798..25146091, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (25093799..25096092, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E5324 Neighboring gene kinase D-interacting substrate 220 Neighboring gene predicted gene, 36236 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25695412-25695595 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25777982-25778091 Neighboring gene STARR-positive B cell enhancer mm9_chr12:25780927-25781228 Neighboring gene predicted gene, 17746 Neighboring gene STARR-positive B cell enhancer mm9_chr12:25850560-25850861 Neighboring gene predicted gene, 36287 Neighboring gene STARR-seq mESC enhancer starr_31772 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25874352-25874553 Neighboring gene predicted gene, 36496

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Id2 is dispensable for Myc-induced epidermal neoplasia. Murphy DJ, et al. Mol Cell Biol, 2004 Mar. PMID 14966287, Free PMC Article
    2. Nucleo-cytoplasmic shuttling of Id2, a negative regulator of basic helix-loop-helix transcription factors. Kurooka H, et al. J Biol Chem, 2005 Feb 11. PMID 15563451
    3. Transcriptional regulator Id2 mediates CD8+ T cell immunity. Cannarile MA, et al. Nat Immunol, 2006 Dec. PMID 17086188
    4. Inhibitor of DNA binding 2 knockdown inhibits the growth and liver metastasis of colorectal cancer. Liu F, et al. Gene, 2022 Apr 20. PMID 35114275
    5. Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis. Sakata-Goto T, et al. Bone, 2012 Jan. PMID 21985998

    See all (487) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elevated Id2 expression causes defective meiosis and spermatogenesis in mice.
      Title: Elevated Id2 expression causes defective meiosis and spermatogenesis in mice.
    2. The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation.
      Title: The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation.
    3. Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells.
      Title: Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells.
    4. BMPR1A promotes ID2-ZEB1 interaction to suppress excessive endothelial to mesenchymal transition.
      Title: BMPR1A promotes ID2-ZEB1 interaction to suppress excessive endothelial to mesenchymal transition.
    5. Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice.
      Title: Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice.
    6. ID2 controls differentiation of enteroendocrine cells in mouse small intestine.
      Title: ID2 controls differentiation of enteroendocrine cells in mouse small intestine.
    7. Inhibitor of DNA binding 2 knockdown inhibits the growth and liver metastasis of colorectal cancer.
      Title: Inhibitor of DNA binding 2 knockdown inhibits the growth and liver metastasis of colorectal cancer.
    8. Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.
      Title: Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.
    9. DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
      Title: DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
    10. Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfbeta-Id2 axis, for tissue regeneration.
      Title: Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration.
    Submit: New GeneRIF Correction See all GeneRIFs (129)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (16)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within Peyer's patch development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of astrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bundle of His development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to lithium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic digestive tract morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endodermal digestive tract morphogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within entrainment of circadian clock IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within enucleate erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epithelial cell differentiation involved in mammary gland alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leukocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymph node development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mammary gland alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membranous septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within natural killer cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of core promoter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of astrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of macrophage differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within thigmotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of white fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding protein inhibitor ID-2
    Names
    inhibitor of differentiation 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010496.3 → NP_034626.1  DNA-binding protein inhibitor ID-2

      See identical proteins and their annotated locations for NP_034626.1

      Status: VALIDATED

      Source sequence(s)
      AK135547, BQ044638
      Consensus CDS
      CCDS25846.1
      UniProtKB/Swiss-Prot
      O88604, P41136
      UniProtKB/TrEMBL
      Q545T4
      Related
      ENSMUSP00000020974.7, ENSMUST00000020974.7
      Conserved Domains (1) summary
      cd19692
      Location:18 → 83
      bHLH_dnHLH_ID2; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      25143798..25146091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41136.3 GenPept UniProtKB/Swiss-Prot:P41136

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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