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    Zfp142 zinc finger protein 142 [ Mus musculus (house mouse) ]

    Gene ID: 77264, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp142provided by MGI
    Official Full Name
    zinc finger protein 142provided by MGI
    Primary source
    MGI:MGI:1924514
    See related
    Ensembl:ENSMUSG00000026135 AllianceGenome:MGI:1924514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf142; mKIAA0236; 9330177B18Rik
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system and inner ear. Orthologous to human ZNF142 (zinc finger protein 142). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 10.5), thymus adult (RPKM 9.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp142 in Genome Data Viewer
    Location:
    1 C4; 1 38.54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74605490..74627308, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74566331..74588133, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9 Neighboring gene phospholipase C, delta 4 Neighboring gene STARR-seq mESC enhancer starr_01339 Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZNF142 mutation causes sex-dependent neurologic disorder. Proskorovski-Ohayon R, et al. J Med Genet, 2024 May 21. PMID 38296634
    2. Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice. Ehringer MA, et al. Alcohol Clin Exp Res, 2002 Nov. PMID 12436047
    3. Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice. Proctor WR, et al. Alcohol Clin Exp Res, 2004 Sep. PMID 15365296
    4. Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Ficker M, et al. Dev Biol, 2004 Apr 1. PMID 15031101
    5. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF142 mutation causes sex-dependent neurologic disorder.
      Title: ZNF142 mutation causes sex-dependent neurologic disorder.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 142

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310668.2 → NP_001297597.1  zinc finger protein 142 isoform 1

      See identical proteins and their annotated locations for NP_001297597.1

      Status: VALIDATED

      Source sequence(s)
      AC117610
      Consensus CDS
      CCDS78619.1
      UniProtKB/Swiss-Prot
      E9PY67, G5E869, Q3V1C1, Q8BWJ0, Q8BWL4, Q8CHH6
      UniProtKB/TrEMBL
      Q925J4
      Related
      ENSMUSP00000027315.8, ENSMUST00000027315.14
      Conserved Domains (4) summary
      COG5048
      Location:335 → 781
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:866 → 1015
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1694 → 1715
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1679 → 1703
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001432003.1 → NP_001418932.1  zinc finger protein 142 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117610
      UniProtKB/Swiss-Prot
      E9PY67, G5E869, Q3V1C1, Q8BWJ0, Q8BWL4, Q8CHH6

    3. NM_001432004.1 → NP_001418933.1  zinc finger protein 142 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117610
      UniProtKB/Swiss-Prot
      E9PY67, G5E869, Q3V1C1, Q8BWJ0, Q8BWL4, Q8CHH6

    4. NM_001432005.1 → NP_001418934.1  zinc finger protein 142 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117610

    5. NM_001432006.1 → NP_001418935.1  zinc finger protein 142 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117610

    6. NM_001432007.1 → NP_001418936.1  zinc finger protein 142 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117610

    7. NM_001432008.1 → NP_001418937.1  zinc finger protein 142 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117610

    8. NM_001432009.1 → NP_001418938.1  zinc finger protein 142 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117610

    9. NM_001432010.1 → NP_001418939.1  zinc finger protein 142 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117610

    10. NM_029888.4 → NP_084164.1  zinc finger protein 142 isoform 2

      See identical proteins and their annotated locations for NP_084164.1

      Status: VALIDATED

      Source sequence(s)
      AC117610
      Consensus CDS
      CCDS35618.1
      UniProtKB/TrEMBL
      Q925J4
      Related
      ENSMUSP00000109366.2, ENSMUST00000113737.8
      Conserved Domains (4) summary
      COG5048
      Location:232 → 678
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:763 → 912
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1591 → 1612
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1576 → 1600
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74605490..74627308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496319.4 → XP_006496382.1  zinc finger protein 142 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:335 → 781
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:866 → 1015
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1694 → 1715
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1679 → 1703
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036154349.1 → XP_036010242.1  zinc finger protein 142 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:144 → 590
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:675 → 824
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1503 → 1524
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1488 → 1512
      zf-H2C2_2; Zinc-finger double domain

    3. XM_036154354.1 → XP_036010247.1  zinc finger protein 142 isoform X5

      UniProtKB/TrEMBL
      Q925J4
      Conserved Domains (4) summary
      COG5048
      Location:22 → 443
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:528 → 677
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1356 → 1377
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1341 → 1365
      zf-H2C2_2; Zinc-finger double domain

    4. XM_030243549.1 → XP_030099409.1  zinc finger protein 142 isoform X4

      UniProtKB/TrEMBL
      Q925J4
      Related
      ENSMUSP00000065149.7, ENSMUST00000066986.13
      Conserved Domains (4) summary
      COG5048
      Location:134 → 580
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:665 → 814
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1493 → 1514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1478 → 1502
      zf-H2C2_2; Zinc-finger double domain

    5. XM_036154348.1 → XP_036010241.1  zinc finger protein 142 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:232 → 678
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:763 → 912
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1591 → 1612
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1576 → 1600
      zf-H2C2_2; Zinc-finger double domain

    6. XM_036154350.1 → XP_036010243.1  zinc finger protein 142 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:134 → 580
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:665 → 814
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1493 → 1514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1478 → 1502
      zf-H2C2_2; Zinc-finger double domain

    7. XM_030243546.1 → XP_030099406.1  zinc finger protein 142 isoform X2

      UniProtKB/TrEMBL
      Q925J4
      Conserved Domains (4) summary
      COG5048
      Location:232 → 678
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:763 → 912
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1591 → 1612
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1576 → 1600
      zf-H2C2_2; Zinc-finger double domain

    8. XM_006496318.3 → XP_006496381.1  zinc finger protein 142 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:335 → 781
      COG5048; FOG: Zn-finger [General function prediction only]
      PRK10811
      Location:866 → 1015
      rne; ribonuclease E; Reviewed
      sd00017
      Location:1694 → 1715
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1679 → 1703
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E869.1 GenPept UniProtKB/Swiss-Prot:G5E869

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