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    Dnajc28 DnaJ heat shock protein family (Hsp40) member C28 [ Mus musculus (house mouse) ]

    Gene ID: 246738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajc28provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C28provided by MGI
    Primary source
    MGI:MGI:2181053
    See related
    Ensembl:ENSMUSG00000039763 AllianceGenome:MGI:2181053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF28
    Summary
    Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human DNAJC28 (DnaJ heat shock protein family (Hsp40) member C28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 4.0), testis adult (RPKM 2.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc28 in Genome Data Viewer
    Location:
    16 C3.3; 16 53.17 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91411142..91415931, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91614257..91618999, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41480 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91588013-91588235 Neighboring gene STARR-positive B cell enhancer ABC_E3173 Neighboring gene STARR-positive B cell enhancer mm9_chr16:91619128-91619428 Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E3174 Neighboring gene STARR-positive B cell enhancer ABC_E7475 Neighboring gene predicted gene, 36712 Neighboring gene Son DNA binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    2. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Chavez JD, et al. Cell Syst, 2018 Jan 24. PMID 29199018, Free PMC Article
    3. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    4. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27620

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 28
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099738.1 → NP_001093208.1  dnaJ homolog subfamily C member 28 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131691, AK081175, AV328433, BB535506, BB622009, BU520154
      Consensus CDS
      CCDS49912.1
      UniProtKB/TrEMBL
      E9Q1L7
      Related
      ENSMUSP00000132288.2, ENSMUST00000169982.2
      Conserved Domains (3) summary
      PLN03085
      Location:224 → 362
      PLN03085; nucleobase:cation symporter-1; Provisional
      pfam00226
      Location:72 → 132
      DnaJ; DnaJ domain
      pfam09350
      Location:227 → 295
      DUF1992; Domain of unknown function (DUF1992)

    2. NM_138664.2 → NP_619605.2  dnaJ homolog subfamily C member 28 isoform 2

      See identical proteins and their annotated locations for NP_619605.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream AUG, compared to variant 1. The resulting protein (isoform 2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC131691, AK081175, AV328433, BB535506, BB622009
      Consensus CDS
      CCDS49911.1
      UniProtKB/Swiss-Prot
      Q8VCE1, Q99JX0
      UniProtKB/TrEMBL
      Q8C4S9
      Related
      ENSMUSP00000048113.9, ENSMUST00000049244.10
      Conserved Domains (4) summary
      PLN03085
      Location:200 → 338
      PLN03085; nucleobase:cation symporter-1; Provisional
      COG2214
      Location:45 → 187
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      pfam00226
      Location:48 → 108
      DnaJ; DnaJ domain
      pfam09350
      Location:203 → 271
      DUF1992; Domain of unknown function (DUF1992)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91411142..91415931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159930.1 → XP_036015823.1  dnaJ homolog subfamily C member 28 isoform X1

      UniProtKB/Swiss-Prot
      Q8VCE1, Q99JX0
      UniProtKB/TrEMBL
      Q8C4S9
      Conserved Domains (4) summary
      PLN03085
      Location:200 → 338
      PLN03085; nucleobase:cation symporter-1; Provisional
      COG2214
      Location:45 → 187
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      pfam00226
      Location:48 → 108
      DnaJ; DnaJ domain
      pfam09350
      Location:203 → 271
      DUF1992; Domain of unknown function (DUF1992)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCE1.2 GenPept UniProtKB/Swiss-Prot:Q8VCE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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