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    Cdc16 CDC16 cell division cycle 16 [ Mus musculus (house mouse) ]

    Gene ID: 69957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc16provided by MGI
    Official Full Name
    CDC16 cell division cycle 16provided by MGI
    Primary source
    MGI:MGI:1917207
    See related
    Ensembl:ENSMUSG00000038416 AllianceGenome:MGI:1917207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APC6; 2700071J12Rik; 2810431D22Rik
    Summary
    Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Located in nucleus. Is expressed in brain; cerebellum; and cerebral cortex. Orthologous to human CDC16 (cell division cycle 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 32.5), CNS E11.5 (RPKM 27.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc16 in Genome Data Viewer
    Location:
    8 A1.1; 8 6.38 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13807650..13831951)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13757649..13781951)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46032 Neighboring gene CFAP97 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_20774 Neighboring gene STARR-seq mESC enhancer starr_20775 Neighboring gene STARR-positive B cell enhancer mm9_chr8:13753700-13754000 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene UPF3 regulator of nonsense transcripts homolog A (yeast) Neighboring gene SUMO/sentrin specific peptidase 2-like 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Fan M, et al. Genes Dev, 2004 Feb 1. PMID 14744933, Free PMC Article
    2. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance. Li N, et al. Oncogenesis, 2019 Feb 19. PMID 30783098, Free PMC Article
    3. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Ferguson CJ, et al. Mol Cell, 2022 Jan 6. PMID 34942119, Free PMC Article
    4. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle protein 16 homolog
    Names
    anaphase-promoting complex subunit 6
    cyclosome subunit 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357247.1 → NP_001344176.1  cell division cycle protein 16 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134623
      Conserved Domains (4) summary
      COG3063
      Location:277 → 417
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      TIGR02917
      Location:135 → 414
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:353 → 379
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:353 → 417
      TPR_12; Tetratricopeptide repeat

    2. NM_027276.3 → NP_081552.2  cell division cycle protein 16 homolog isoform 1

      See identical proteins and their annotated locations for NP_081552.2

      Status: VALIDATED

      Source sequence(s)
      AC134623, AK147938
      Consensus CDS
      CCDS22114.1
      UniProtKB/Swiss-Prot
      Q8R349, Q9CYX9
      UniProtKB/TrEMBL
      Q3TI84
      Related
      ENSMUSP00000047950.9, ENSMUST00000043962.9
      Conserved Domains (4) summary
      smart00028
      Location:448 → 478
      TPR; Tetratricopeptide repeats
      sd00006
      Location:447 → 473
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:15 → 94
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:447 → 509
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13807650..13831951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154276.1 → XP_036010169.1  cell division cycle protein 16 homolog isoform X2

      Conserved Domains (3) summary
      COG3063
      Location:65 → 205
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      sd00006
      Location:141 → 167
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:141 → 205
      TPR_12; Tetratricopeptide repeat

    2. XM_006508882.4 → XP_006508945.1  cell division cycle protein 16 homolog isoform X1

      See identical proteins and their annotated locations for XP_006508945.1

      Conserved Domains (4) summary
      COG3063
      Location:277 → 417
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      TIGR02917
      Location:135 → 414
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:353 → 379
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:353 → 417
      TPR_12; Tetratricopeptide repeat

    3. XM_036154277.1 → XP_036010170.1  cell division cycle protein 16 homolog isoform X2

      Conserved Domains (3) summary
      COG3063
      Location:65 → 205
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      sd00006
      Location:141 → 167
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:141 → 205
      TPR_12; Tetratricopeptide repeat

    RNA

    1. XR_004934874.1 RNA Sequence

    2. XR_004934875.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R349.1 GenPept UniProtKB/Swiss-Prot:Q8R349

    Gene LinkOut

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