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    Syngr1 synaptogyrin 1 [ Mus musculus (house mouse) ]

    Gene ID: 20972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syngr1provided by MGI
    Official Full Name
    synaptogyrin 1provided by MGI
    Primary source
    MGI:MGI:1328323
    See related
    Ensembl:ENSMUSG00000022415 AllianceGenome:MGI:1328323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p29; Syngr1b
    Summary
    Involved in regulation of long-term neuronal synaptic plasticity and regulation of short-term neuronal synaptic plasticity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human SYNGR1 (synaptogyrin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 56.1), cortex adult (RPKM 51.4) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syngr1 in Genome Data Viewer
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79975537..80003702)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80091334..80119501)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 43 Neighboring gene ribosomal protein L3 Neighboring gene predicted gene, 24204 Neighboring gene predicted gene, 31134 Neighboring gene STARR-seq mESC enhancer starr_39220 Neighboring gene STARR-seq mESC enhancer starr_39222 Neighboring gene STARR-positive B cell enhancer ABC_E10868 Neighboring gene predicted gene, 31253 Neighboring gene STARR-seq mESC enhancer starr_39224 Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 1 Neighboring gene mannoside acetylglucosaminyltransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice. Häggman Henrikson J, et al. Brain Res Bull, 2020 Feb. PMID 31805305
    2. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. Raja MK, et al. Elife, 2019 May 15. PMID 31090538, Free PMC Article
    3. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Janz R, et al. Neuron, 1999 Nov. PMID 10595519
    4. Characterization of synaptogyrin 3 as a new synaptic vesicle protein. Belizaire R, et al. J Comp Neurol, 2004 Mar 8. PMID 14755516
    5. Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells. Belfort GM, et al. J Biol Chem, 2003 Nov 28. PMID 12928441

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice.
      Title: Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice.
    2. Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment
      Title: Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of short-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptogyrin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411782.1 → NP_001398711.1  synaptogyrin-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a different segment for its 5' UTR, 5' coding region, 3' coding region, and 3' UTR, as compared to variant 1a. The encoded isoform (2) has distinct N- and C-termini, compared to isoform 1a.
      Source sequence(s)
      AC161199

    2. NM_001411783.1 → NP_001398712.1  synaptogyrin-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes a different segment for its 5' UTR and 5' coding region, as compared to variant 1a. The encoded isoform (3) has a distinct N-terminus, compared to isoform 1a.
      Source sequence(s)
      AC161199

    3. NM_009303.3 → NP_033329.1  synaptogyrin-1 isoform 1b

      See identical proteins and their annotated locations for NP_033329.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1b) includes a different segment for its 3' coding region and 3' UTR, as compared to variant 1a. The encoded isoform (1b) has a distinct and shorter C-terminus, compared to isoform 1a.
      Source sequence(s)
      AC161199
      Consensus CDS
      CCDS27658.1
      UniProtKB/TrEMBL
      Q3U6D7
      Related
      ENSMUSP00000009728.7, ENSMUST00000009728.13
      Conserved Domains (1) summary
      pfam01284
      Location:21 → 167
      MARVEL; Membrane-associating domain

    4. NM_207708.2 → NP_997591.1  synaptogyrin-1 isoform 1a

      See identical proteins and their annotated locations for NP_997591.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1a) encodes the longest protein (isoform 1a).
      Source sequence(s)
      AC161199
      Consensus CDS
      CCDS27657.1
      UniProtKB/Swiss-Prot
      B9EI16, O55100, Q543Y5, Q9DCB0
      Related
      ENSMUSP00000009727.6, ENSMUST00000009727.12
      Conserved Domains (1) summary
      pfam01284
      Location:21 → 167
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79975537..80003702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55100.2 GenPept UniProtKB/Swiss-Prot:O55100

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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