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    Arglu1 arginine and glutamate rich 1 [ Mus musculus (house mouse) ]

    Gene ID: 234023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arglu1provided by MGI
    Official Full Name
    arginine and glutamate rich 1provided by MGI
    Primary source
    MGI:MGI:2442985
    See related
    Ensembl:ENSMUSG00000040459 AllianceGenome:MGI:2442985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130008N12; 9430010O03Rik
    Summary
    Enables nuclear receptor coactivator activity and pre-mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and leg muscle. Orthologous to human ARGLU1 (arginine and glutamate rich 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 64.7), CNS E14 (RPKM 55.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arglu1 in Genome Data Viewer
    Location:
    8 A1.1; 8 3.57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (8716307..8741818, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (8666297..8690550, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31463 Neighboring gene STARR-seq mESC enhancer starr_20662 Neighboring gene ephrin B2 Neighboring gene RIKEN cDNA 4921522P10 gene Neighboring gene STARR-seq mESC enhancer starr_20669 Neighboring gene microRNA 7654 Neighboring gene IKAROS family zinc finger 5 pseudogene Neighboring gene predicted gene, 39127 Neighboring gene STARR-seq mESC enhancer starr_20671

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. Magomedova L, et al. Nucleic Acids Res, 2019 Apr 8. PMID 30698747, Free PMC Article
    2. Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis. Yao F, et al. Cell Death Dis, 2023 Aug 23. PMID 37612280, Free PMC Article
    3. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis.
      Title: Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear receptor coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arginine and glutamate-rich protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176849.3 → NP_789819.2  arginine and glutamate-rich protein 1

      See identical proteins and their annotated locations for NP_789819.2

      Status: VALIDATED

      Source sequence(s)
      BC029219, BU514203, BY756892, CB528163
      Consensus CDS
      CCDS40215.1
      UniProtKB/Swiss-Prot
      Q3UL36, Q80XJ0
      Related
      ENSMUSP00000039493.9, ENSMUST00000048545.10
      Conserved Domains (1) summary
      pfam15346
      Location:128 → 267
      ARGLU; Arginine and glutamate-rich 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      8716307..8741818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508760.5 → XP_006508823.1  arginine and glutamate-rich protein 1 isoform X2

      Conserved Domains (1) summary
      pfam15346
      Location:80 → 219
      ARGLU; Arginine and glutamate-rich 1

    2. XM_006508759.5 → XP_006508822.1  arginine and glutamate-rich protein 1 isoform X1

      Conserved Domains (1) summary
      pfam15346
      Location:110 → 249
      ARGLU; Arginine and glutamate-rich 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UL36.2 GenPept UniProtKB/Swiss-Prot:Q3UL36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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