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    Tmub1 transmembrane and ubiquitin-like domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 64295, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmub1provided by MGI
    Official Full Name
    transmembrane and ubiquitin-like domain containing 1provided by MGI
    Primary source
    MGI:MGI:1923764
    See related
    Ensembl:ENSMUSG00000028958 AllianceGenome:MGI:1923764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hops; 2010004O20Rik
    Summary
    Predicted to be involved in ERAD pathway. Predicted to be located in several cellular components, including centrosome; postsynaptic membrane; and recycling endosome. Orthologous to human TMUB1 (transmembrane and ubiquitin like domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 41.2), colon adult (RPKM 38.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmub1 in Genome Data Viewer
    Location:
    5 A3; 5 11.79 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24650461..24652859, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24445463..24447846, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 (anion exchanger), member 2 Neighboring gene predicted gene, 22333 Neighboring gene Fas-activated serine/threonine kinase Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene VISTA enhancer mm1191 Neighboring gene gastrulation brain homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional expression and localisation of HOPS/TMUB1 in mouse lens. Bartoli D, et al. Biosci Rep, 2021 Feb 26. PMID 33543240, Free PMC Article
    2. HOPS is an essential constituent of centrosome assembly. Pieroni S, et al. Cell Cycle, 2008 May 15. PMID 18418082
    3. Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis. Ferracchiato S, et al. Int J Mol Sci, 2021 Jul 2. PMID 34281239, Free PMC Article
    4. Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation. Fu H, et al. Cell Signal, 2019 Mar. PMID 30610893
    5. Hepatocyte odd protein shuttling (HOPS) is a bridging protein in the nucleophosmin-p19 Arf network. Castelli M, et al. Oncogene, 2013 Jul 11. PMID 22890319

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional expression and localisation of HOPS/TMUB1 in mouse lens.
      Title: Functional expression and localisation of HOPS/TMUB1 in mouse lens.
    2. Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis.
      Title: Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis.
    3. HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6.
      Title: HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6.
    4. HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis.
      Title: HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis.
    5. The results of this study suggest that Tmub1 is an important negative regulator of hepatocyte proliferation in liver regeneration through STAT3 (signal transducer and activator of transcription 3 protein) signaling.
      Title: Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation.
    6. HOPS has distinct, isoform-specific functions in the nucleolus, nucleus, and cytoplasm.
      Title: Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system.
    7. HOPS acts as a functional bridge in the interaction between NPM and p19(Arf)
      Title: Hepatocyte odd protein shuttling (HOPS) is a bridging protein in the nucleophosmin-p19 Arf network.
    8. results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG
      Title: Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.
    9. transmission; it contributes to maintain the synaptic surface number of the GluR2-containing AMPARs by facilitating the recycling of GluR2 to the plasma membrane
      Title: Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors.
    10. HOPS is involved in centrosome assembly and maintenance.
      Title: HOPS is an essential constituent of centrosome assembly.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and ubiquitin-like domain-containing protein 1
    Names
    hepatocyte odd protein shuttling protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022418.3 → NP_071863.1  transmembrane and ubiquitin-like domain-containing protein 1

      See identical proteins and their annotated locations for NP_071863.1

      Status: VALIDATED

      Source sequence(s)
      AB030183, BB871344
      Consensus CDS
      CCDS19121.1
      UniProtKB/Swiss-Prot
      Q53AQ3, Q9JMG3
      UniProtKB/TrEMBL
      E9QN77
      Related
      ENSMUSP00000030799.9, ENSMUST00000030799.15
      Conserved Domains (1) summary
      cd17131
      Location:101 → 171
      Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      24650461..24652859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535786.3 → XP_006535849.1  transmembrane and ubiquitin-like domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006535849.1

      UniProtKB/Swiss-Prot
      Q53AQ3, Q9JMG3
      UniProtKB/TrEMBL
      E9QN77
      Conserved Domains (1) summary
      cd17131
      Location:101 → 171
      Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMG3.1 GenPept UniProtKB/Swiss-Prot:Q9JMG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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