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    Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnab1provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, beta member 1provided by MGI
    Primary source
    MGI:MGI:109155
    See related
    Ensembl:ENSMUSG00000027827 AllianceGenome:MGI:109155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akr8a8; Kvbeta1.1; mKv(beta)1
    Summary
    Predicted to enable several functions, including NADPH binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Acts upstream of or within learning or memory and regulation of potassium ion transmembrane transporter activity. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and perikaryon. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in juxtaparanode region of axon. Is expressed in brain; heart; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 15.7), cortex adult (RPKM 8.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnab1 in Genome Data Viewer
    Location:
    3 E1; 3 30.15 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (64856636..65285643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (64949212..65378225)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 13 Neighboring gene predicted gene, 25222 Neighboring gene STARR-seq mESC enhancer starr_07851 Neighboring gene predicted gene, 54196 Neighboring gene STARR-seq mESC enhancer starr_07852 Neighboring gene STARR-seq mESC enhancer starr_07853 Neighboring gene RIKEN cDNA A330015K06 gene Neighboring gene STARR-seq mESC enhancer starr_07854 Neighboring gene RIKEN cDNA A730090N16 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:65123524-65123825 Neighboring gene STARR-positive B cell enhancer ABC_E517 Neighboring gene acyl-CoA synthetase family member 2 pseudogene Neighboring gene signal sequence receptor, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice. Murphy GG, et al. Curr Biol, 2004 Nov 9. PMID 15530391
    2. Mouse brain potassium channel beta1 subunit mRNA: cloning and distribution during development. Butler DM, et al. J Neurobiol, 1998 Feb 5. PMID 9468385
    3. Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Giese KP, et al. Learn Mem, 1998 Sep-Oct. PMID 10454353, Free PMC Article
    4. Ion channel proteins in mouse and human vestibular tissue. Hotchkiss K, et al. Otolaryngol Head Neck Surg, 2005 Jun. PMID 15944564
    5. Learning and memory impairments in Kv beta 1.1-null mutants are rescued by environmental enrichment or ageing. Need AC, et al. Eur J Neurosci, 2003 Sep. PMID 14511342

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins.
      Title: Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
    2. Data, including data from studies in knockout mice, suggest that association/disassociation of subunits Kcnma1 and Kcnab1 of the BK channel (large-conductance calcium-activated potassium channel) is involved in function of coronary artery smooth muscle cells and their dysfunction during ischemia/reperfusion-induced myocardial injury in diabetes.
      Title: Coronary arterial BK channel dysfunction exacerbates ischemia/reperfusion-induced myocardial injury in diabetic mice.
    3. Kvbeta1 differentially regulates the functional cell surface expression of myocardial I(to,f) and I(K,slow2) channels.
      Title: Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldo-keto reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldo-keto reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbonyl reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of potassium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in juxtaparanode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel subunit beta-1
    Names
    K(+) channel subunit beta-1
    voltage dependent potassium channel subunit beta-1
    NP_001276379.1
    NP_001344287.1
    NP_001390801.1
    NP_034727.3
    XP_006501120.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289450.2 → NP_001276379.1  voltage-gated potassium channel subunit beta-1 isoform 2

      See identical proteins and their annotated locations for NP_001276379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC113279, AC119855, AC134550
      UniProtKB/TrEMBL
      Q3U6C5, Q9D5E9
      Related
      ENSMUST00000161404.8
      Conserved Domains (1) summary
      cl00470
      Location:1 → 287
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    2. NM_001357358.2 → NP_001344287.1  voltage-gated potassium channel subunit beta-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113279, AC113458, AC134550
      Consensus CDS
      CCDS89632.1
      UniProtKB/TrEMBL
      A0A5F8MPK0
      Related
      ENSMUSP00000159000.2, ENSMUST00000238901.2
      Conserved Domains (1) summary
      TIGR01293
      Location:91 → 407
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    3. NM_001403872.1 → NP_001390801.1  voltage-gated potassium channel subunit beta-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113458, AC134550
      UniProtKB/TrEMBL
      Q8CD65
      Related
      ENSMUST00000159525.8

    4. NM_010597.6 → NP_034727.3  voltage-gated potassium channel subunit beta-1 isoform 1

      See identical proteins and their annotated locations for NP_034727.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC113279, AC113458, AC134550
      Consensus CDS
      CCDS38447.1
      UniProtKB/Swiss-Prot
      P63143, P97380, Q61763, Q63277, Q91WM5
      UniProtKB/TrEMBL
      Q9D5E9
      Related
      ENSMUSP00000047480.9, ENSMUST00000049230.11
      Conserved Domains (1) summary
      cd19159
      Location:71 → 393
      AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      64856636..65285643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501057.1 → XP_006501120.1  voltage-gated potassium channel subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPA4, Q9D5E9
      Related
      ENSMUSP00000158882.2, ENSMUST00000239069.2
      Conserved Domains (1) summary
      cd19159
      Location:78 → 400
      AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63143.2 GenPept UniProtKB/Swiss-Prot:P63143

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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