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    Lamp5 lysosomal-associated membrane protein family, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 76161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lamp5provided by MGI
    Official Full Name
    lysosomal-associated membrane protein family, member 5provided by MGI
    Primary source
    MGI:MGI:1923411
    See related
    Ensembl:ENSMUSG00000027270 AllianceGenome:MGI:1923411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAMP-5; BAD-LAMP; 3110035N03Rik; 6330527O06Rik
    Summary
    Involved in presynaptic modulation of chemical synaptic transmission. Located in several cellular components, including dendrite membrane; endosome; and growth cone membrane. Is active in GABA-ergic synapse and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; vertebral axis musculature; and vibrissa. Orthologous to human LAMP5 (lysosomal associated membrane protein family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 56.6), frontal lobe adult (RPKM 36.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lamp5 in Genome Data Viewer
    Location:
    2 F3; 2 67.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (135893945..135911837)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (136052025..136069917)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phospholipase C, beta 4 Neighboring gene STARR-seq mESC enhancer starr_05795 Neighboring gene predicted gene, 54133 Neighboring gene predicted gene, 26227 Neighboring gene STARR-seq mESC enhancer starr_05797 Neighboring gene p21 (RAC1) activated kinase 5 Neighboring gene predicted gene 14218 Neighboring gene predicted gene, 39942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing. Koebis M, et al. Mol Brain, 2019 Mar 12. PMID 30867010, Free PMC Article
    2. LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain. Tiveron MC, et al. PLoS One, 2016. PMID 27272053, Free PMC Article
    3. Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease. Deng Y, et al. Acta Neuropathol, 2022 Oct. PMID 35780436, Free PMC Article
    4. BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons. David A, et al. J Cell Sci, 2007 Jan 15. PMID 17215451
    5. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. Kizuka Y, et al. EMBO Mol Med, 2015 Feb. PMID 25592972, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease.
      Title: Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease.
    2. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord.
      Title: LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing.
    3. Results show that in mice LAMP5 protein is specifically expressed in subpopulations of GABAergic neurons where it localizes at synaptic terminals, overlapping with VGAT and provide evidence for a fine-tuning function of LAMP5 in evoked GABAergic synaptic transmission.
      Title: LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in growth cone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysosome-associated membrane glycoprotein 5
    Names
    LAMP family protein C20orf103 homolog
    Protein C20orf103
    brain and dendritic cell-associated LAMP
    brain-associated LAMP-like protein
    lysosome-associated membrane protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356548.1 → NP_001343477.1  lysosome-associated membrane glycoprotein 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL845354, AL928798
      Consensus CDS
      CCDS16789.1
      UniProtKB/Swiss-Prot
      Q9CXQ4, Q9D387
      Conserved Domains (1) summary
      pfam01299
      Location:43 → 213
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    2. NM_029530.3 → NP_083806.2  lysosome-associated membrane glycoprotein 5 precursor

      See identical proteins and their annotated locations for NP_083806.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL845354, AL928798
      Consensus CDS
      CCDS16789.1
      UniProtKB/Swiss-Prot
      Q9CXQ4, Q9D387
      Related
      ENSMUSP00000061180.7, ENSMUST00000057503.7
      Conserved Domains (1) summary
      pfam01299
      Location:43 → 213
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      135893945..135911837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319318.2 → XP_017174807.1  lysosome-associated membrane glycoprotein 5 isoform X2

      UniProtKB/Swiss-Prot
      Q9D387
      Conserved Domains (1) summary
      pfam01299
      Location:24 → 95
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    2. XM_036162664.1 → XP_036018557.1  lysosome-associated membrane glycoprotein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q9CXQ4, Q9D387
      Conserved Domains (1) summary
      pfam01299
      Location:43 → 213
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    RNA

    1. XR_004940765.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D387.2 GenPept UniProtKB/Swiss-Prot:Q9D387

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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