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    C1d C1D nuclear receptor co-repressor [ Mus musculus (house mouse) ]

    Gene ID: 57316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C1dprovided by MGI
    Official Full Name
    C1D nuclear receptor co-repressorprovided by MGI
    Primary source
    MGI:MGI:1927354
    See related
    Ensembl:ENSMUSG00000000581 AllianceGenome:MGI:1927354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SUN-CoR; 1110036E10Rik
    Summary
    Enables DNA binding activity; nuclear receptor binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription. Part of transcription repressor complex. Is expressed in limb and limb mesenchyme. Orthologous to human C1D (C1D nuclear receptor corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 11.9), CNS E14 (RPKM 8.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1d in Genome Data Viewer
    Location:
    11 A2; 11 9.89 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (17207547..17219176)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (17257547..17269176)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3933 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:17111656-17111843 Neighboring gene partner of NOB1 homolog Neighboring gene dynein axonemal assembly factor 10 Neighboring gene STARR-seq mESC enhancer starr_28705 Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28707 Neighboring gene predicted gene, 31268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response. Jackson RA, et al. Cell Div, 2016. PMID 27030795, Free PMC Article
    2. cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity. Nehls P, et al. Nucleic Acids Res, 1998 Mar 1. PMID 9469821, Free PMC Article
    3. Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. Zamir I, et al. Proc Natl Acad Sci U S A, 1997 Dec 23. PMID 9405624, Free PMC Article
    4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of 5.8S rRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear nucleic acid-binding protein C1D
    Names
    nuclear DNA-binding protein
    small unique nuclear receptor corepressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330649.1 → NP_001317578.1  nuclear nucleic acid-binding protein C1D

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI430211, AK028702, AK035169, AL603925
      Consensus CDS
      CCDS24451.1
      UniProtKB/Swiss-Prot
      O35473, Q5SWJ6, Q61368
      UniProtKB/TrEMBL
      A0A0A0MQK7
      Related
      ENSMUSP00000121134.2, ENSMUST00000156784.2
      Conserved Domains (1) summary
      pfam04000
      Location:18 → 95
      Sas10_Utp3; Sas10/Utp3/C1D family

    2. NM_020558.4 → NP_065583.2  nuclear nucleic acid-binding protein C1D

      See identical proteins and their annotated locations for NP_065583.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK028702, AK035169, AL603925
      Consensus CDS
      CCDS24451.1
      UniProtKB/Swiss-Prot
      O35473, Q5SWJ6, Q61368
      UniProtKB/TrEMBL
      A0A0A0MQK7
      Related
      ENSMUSP00000000594.3, ENSMUST00000000594.9
      Conserved Domains (1) summary
      pfam04000
      Location:18 → 95
      Sas10_Utp3; Sas10/Utp3/C1D family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      17207547..17219176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35473.1 GenPept UniProtKB/Swiss-Prot:O35473

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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