Klrc1 killer cell lectin-like receptor subfamily C, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klrc1provided by MGI
Official Full Name: killer cell lectin-like receptor subfamily C, member 1provided by MGI
Primary source: MGI:MGI:1336161
See related: Ensembl:ENSMUSG00000030167 AllianceGenome:MGI:1336161
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NKG2A; NKG2B; CD159a
Summary: Predicted to enable HLA-E specific inhibitory MHC class Ib receptor activity and MHC class I protein complex binding activity. Predicted to be involved in positive regulation of natural killer cell mediated cytotoxicity and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Is expressed in liver. Orthologous to several human genes including KLRC1 (killer cell lectin like receptor C1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129642978..129659815, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129666015..129682852, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.
Title: KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.
Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors.
Title: Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors.
NKG2A downregulation evades the HLA-E cancer immune-checkpoint, and increases the anti-tumor activity of NK cell infusions
Title: Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.
Data suggest that NKG2A Receptor (NKG2A) and the inhibitory members of NK cell lectin-like receptor subfamily A (Ly49) family receptors synergize to regulate NK cell education.
Title: Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus.
Title: Evidence of functional Cd94 polymorphism in a free-living house mouse population.
Liver cNK cells' hyporesponsiveness to stimulation through activating receptors is independent of IL-10, but correlates with decreased NKG2A expression compared to trNK cells.
Title: Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement.
Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis.
Title: The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.
NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection.
Title: The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.
Results demonstrate the immunoregulatory role of CD8(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance.
Title: Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.
role in NK cell-mediated protection from DSS-induced colitis
Title: Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492586

Klrc1 (e-PCR), detects polymorphism
- UniSTS:532621

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables HLA-E specific inhibitory MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
enables MHC class I protein complex binding	ISO Inferred from Sequence Orthology more info
enables inhibitory MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in stimulatory C-type lectin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NKG2-A/NKG2-B type II integral membrane protein

Names: Cluster of Differentiation 159a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136068.2 → NP_001129540.1 NKG2-A/NKG2-B type II integral membrane protein isoform 1

See identical proteins and their annotated locations for NP_001129540.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC171002, AF106008

Consensus CDS

CCDS51926.1

UniProtKB/TrEMBL

A6H5Z4, Q9Z202

Related

ENSMUSP00000032270.7, ENSMUST00000032270.13

Conserved Domains (1) summary

cd03593
Location:128 → 240

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_001288664.1 → NP_001275593.1 NKG2-A/NKG2-B type II integral membrane protein isoform 3

See identical proteins and their annotated locations for NP_001275593.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.

Source sequence(s)

AC171002, AF106008, AF106009

Consensus CDS

CCDS80621.1

UniProtKB/TrEMBL

E9QAJ6, Q9WVJ8

Related

ENSMUSP00000130762.2, ENSMUST00000169545.8

Conserved Domains (1) summary

cd03593
Location:94 → 206

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_010652.2 → NP_034782.1 NKG2-A/NKG2-B type II integral membrane protein isoform 2

See identical proteins and their annotated locations for NP_034782.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC171002, AF106008, AF109784

Consensus CDS

CCDS39663.1

UniProtKB/TrEMBL

A6H5Z4, Q9WU32

Related

ENSMUSP00000114017.2, ENSMUST00000118447.2

Conserved Domains (1) summary

cd03593
Location:111 → 223

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

129642978..129659815 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321418.1 → XP_017176907.1 NKG2-A/NKG2-B type II integral membrane protein isoform X3

UniProtKB/TrEMBL

E9QAJ6, Q9WVJ8

Conserved Domains (1) summary

cd03593
Location:94 → 206

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
XM_011241237.1 → XP_011239539.1 NKG2-A/NKG2-B type II integral membrane protein isoform X2

See identical proteins and their annotated locations for XP_011239539.1

UniProtKB/TrEMBL

A6H5Z4, Q9WU32

Conserved Domains (1) summary

cd03593
Location:111 → 223

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
XM_011241236.1 → XP_011239538.1 NKG2-A/NKG2-B type II integral membrane protein isoform X1

See identical proteins and their annotated locations for XP_011239538.1

UniProtKB/TrEMBL

A6H5Z4, Q9Z202

Conserved Domains (1) summary

cd03593
Location:128 → 240

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)