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    Tmprss5 transmembrane protease, serine 5 (spinesin) [ Mus musculus (house mouse) ]

    Gene ID: 80893, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmprss5provided by MGI
    Official Full Name
    transmembrane protease, serine 5 (spinesin)provided by MGI
    Primary source
    MGI:MGI:1933407
    See related
    Ensembl:ENSMUSG00000032268 AllianceGenome:MGI:1933407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    spinesin
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in neuronal cell body. Orthologous to human TMPRSS5 (transmembrane serine protease 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 2.0), stomach adult (RPKM 1.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmprss5 in Genome Data Viewer
    Location:
    9 A5.3; 9 26.59 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (49013994..49028891)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (49079274..49117591)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24085 Neighboring gene claudin 25 Neighboring gene zw10 kinetochore protein Neighboring gene STARR-seq mESC enhancer starr_24086 Neighboring gene STARR-seq mESC enhancer starr_24087 Neighboring gene STARR-seq mESC enhancer starr_24088 Neighboring gene STARR-seq mESC enhancer starr_24089 Neighboring gene predicted gene 4894 Neighboring gene STARR-seq mESC enhancer starr_24090 Neighboring gene dopamine receptor D2 Neighboring gene STARR-seq mESC enhancer starr_24091 Neighboring gene predicted gene, 46111

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5. Watanabe Y, et al. Biochem Biophys Res Commun, 2004 Nov 5. PMID 15465023
    2. cAMP-dependent regulation of spinesin/TMPRSS5 gene expression in astrocytes. Yamaguchi T, et al. J Neurosci Res, 2008 Feb 15. PMID 17918741
    3. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Guipponi M, et al. Hum Mutat, 2008 Jan. PMID 17918732
    4. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 5
    NP_001346389.1
    NP_001408238.1
    NP_109634.2
    XP_006510772.1
    XP_036011307.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359460.2 → NP_001346389.1  transmembrane protease serine 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159825, AC160137
      Consensus CDS
      CCDS90560.1
      UniProtKB/Swiss-Prot
      E9Q2A5, Q9ER02, Q9ER03, Q9ER04
      UniProtKB/TrEMBL
      Q8CDR0
      Related
      ENSMUSP00000132181.2, ENSMUST00000165088.8
      Conserved Domains (2) summary
      smart00020
      Location:217 → 448
      Tryp_SPc; Trypsin-like serine protease
      pfam15494
      Location:116 → 213
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. NM_001421309.1 → NP_001408238.1  transmembrane protease serine 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159825, AC160137

    3. NM_030709.3 → NP_109634.2  transmembrane protease serine 5 isoform 2

      See identical proteins and their annotated locations for NP_109634.2

      Status: VALIDATED

      Source sequence(s)
      AC159825, AC160137
      Consensus CDS
      CCDS52789.1
      UniProtKB/TrEMBL
      A2RSL0, B7ZN60
      Related
      ENSMUSP00000064527.6, ENSMUST00000070390.12
      Conserved Domains (2) summary
      smart00020
      Location:207 → 438
      Tryp_SPc; Trypsin-like serine protease
      pfam15494
      Location:106 → 203
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      49013994..49028891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155414.1 → XP_036011307.1  transmembrane protease serine 5 isoform X3

      UniProtKB/TrEMBL
      E9PWX9
      Conserved Domains (2) summary
      smart00020
      Location:73 → 304
      Tryp_SPc; Trypsin-like serine protease
      pfam15494
      Location:3 → 69
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. XM_006510709.3 → XP_006510772.1  transmembrane protease serine 5 isoform X1

      UniProtKB/TrEMBL
      Q8CDR0
      Related
      ENSMUSP00000131650.2, ENSMUST00000167095.8
      Conserved Domains (2) summary
      smart00020
      Location:184 → 415
      Tryp_SPc; Trypsin-like serine protease
      pfam15494
      Location:83 → 180
      SRCR_2; Scavenger receptor cysteine-rich domain

    RNA

    1. XR_004935609.1 RNA Sequence

    2. XR_004935610.1 RNA Sequence

    3. XR_001779076.2 RNA Sequence

      Related
      ENSMUST00000166272.8

    4. XR_001779075.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER04.3 GenPept UniProtKB/Swiss-Prot:Q9ER04

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