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    Zfp874b zinc finger protein 874b [ Mus musculus (house mouse) ]

    Gene ID: 408067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp874bprovided by MGI
    Official Full Name
    zinc finger protein 874bprovided by MGI
    Primary source
    MGI:MGI:3040702
    See related
    Ensembl:ENSMUSG00000059839 AllianceGenome:MGI:3040702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rslcan16; 9630025I21Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF429 (zinc finger protein 429). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 1.6), bladder adult (RPKM 1.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See Zfp874b in Genome Data Viewer
    Location:
    13 B3; 13 34.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67619632..67634360, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67471513..67486241, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 874a Neighboring gene STARR-seq mESC enhancer starr_34904 Neighboring gene predicted gene 7928 Neighboring gene STARR-positive B cell enhancer ABC_E5405 Neighboring gene zinc finger protein 58 Neighboring gene STARR-positive B cell enhancer ABC_E8532 Neighboring gene zinc finger protein 458 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2. Krebs CJ, et al. Genomics, 2005 Jun. PMID 15885501
    2. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 874b
    Names
    regulator of sex-limitation candidate 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076791.2 → NP_001070259.1  zinc finger protein 874b

      See identical proteins and their annotated locations for NP_001070259.1

      Status: VALIDATED

      Source sequence(s)
      AC154510, BK001633, BY228006, CF727126
      Consensus CDS
      CCDS49302.1
      UniProtKB/TrEMBL
      Q7M6X2
      Related
      ENSMUSP00000019572.7, ENSMUST00000019572.9
      Conserved Domains (5) summary
      smart00349
      Location:5 → 59
      KRAB; krueppel associated box
      COG5048
      Location:143 → 423
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:166 → 186
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 44
      KRAB; KRAB box
      pfam13465
      Location:178 → 203
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67619632..67634360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244536.2 → XP_011242838.1  zinc finger protein 874b isoform X2

      See identical proteins and their annotated locations for XP_011242838.1

      Conserved Domains (3) summary
      smart00349
      Location:2 → 56
      KRAB; krueppel associated box
      COG5048
      Location:140 → 420
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:163 → 183
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011244535.2 → XP_011242837.1  zinc finger protein 874b isoform X2

      See identical proteins and their annotated locations for XP_011242837.1

      Conserved Domains (3) summary
      smart00349
      Location:2 → 56
      KRAB; krueppel associated box
      COG5048
      Location:140 → 420
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:163 → 183
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030247316.1 → XP_030103176.1  zinc finger protein 874b isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:48 → 328
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:71 → 91
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_030247315.1 → XP_030103175.1  zinc finger protein 874b isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:48 → 328
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:71 → 91
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_030247318.1 → XP_030103178.1  zinc finger protein 874b isoform X4

      UniProtKB/TrEMBL
      A0A286YDP7
      Conserved Domains (1) summary
      smart00349
      Location:9 → 63
      KRAB; krueppel associated box

    6. XM_006517283.3 → XP_006517346.1  zinc finger protein 874b isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:9 → 63
      KRAB; krueppel associated box
      COG5048
      Location:147 → 427
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:170 → 190
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_036158084.1 → XP_036013977.1  zinc finger protein 874b isoform X2

      Conserved Domains (3) summary
      smart00349
      Location:2 → 56
      KRAB; krueppel associated box
      COG5048
      Location:140 → 420
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:163 → 183
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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