Sftpd surfactant associated protein D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sftpdprovided by MGI
Official Full Name: surfactant associated protein Dprovided by MGI
Primary source: MGI:MGI:109515
See related: Ensembl:ENSMUSG00000021795 AllianceGenome:MGI:109515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SP-D; Sfpd; Sftp4
Summary: Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in cytoplasm. Is expressed in epidermis spinous layer; lung; lung surfactant; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward lung adult (RPKM 105.6) See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 22.36 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (40894169..40907155, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (41172212..41185198, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx.
Title: Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx.
Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha.
Title: Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.
Immunomodulatory Role of Surfactant Protein-D in a Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model.
Title: Immunomodulatory Role of Surfactant Protein-D in a Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model.
Surfactant protein D is a biomarker of influenza-related pediatric lung injury.
Title: Surfactant protein D is a biomarker of influenza-related pediatric lung injury.
Lower Oligomeric Form of Surfactant Protein D in Murine Acute Lung Injury Induces M1 Subtype Macrophages Through Calreticulin/p38 MAPK Signaling Pathway.
Title: Lower Oligomeric Form of Surfactant Protein D in Murine Acute Lung Injury Induces M1 Subtype Macrophages Through Calreticulin/p38 MAPK Signaling Pathway.
miR-199a-5p Exacerbated Intestinal Barrier Dysfunction through Inhibiting Surfactant Protein D and Activating NF-kappaB Pathway in Sepsis.
Title: miR-199a-5p Exacerbated Intestinal Barrier Dysfunction through Inhibiting Surfactant Protein D and Activating NF-κB Pathway in Sepsis.
MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D.
Title: MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D.
The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease.
Title: The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease.
SP-D exerts protective effects against acute lung injury via suppressing NLRP3 inflammasome and NF-kappaB activation in experimental severe acute pancreatitis
Title: Surfactant Protein D Dampens Lung Injury by Suppressing NLRP3 Inflammasome Activation and NF-κB Signaling in Acute Pancreatitis.
SP-D modulation of pulmonary macrophage phenotype is controlled by S-nitrosylation.
Title: Surfactant protein-D modulation of pulmonary macrophage phenotype is controlled by S-nitrosylation.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237170

Sftpd (e-PCR), detects polymorphism
- UniSTS:516723

AI573415 (e-PCR)
- UniSTS:185997

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables monosaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in opsonization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info
involved_in surfactant homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in surfactant homeostasis	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pulmonary surfactant-associated protein D

Names: PSP-D; lung surfactant protein D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009160.2 → NP_033186.1 pulmonary surfactant-associated protein D precursor

See identical proteins and their annotated locations for NP_033186.1

Status: VALIDATED

Source sequence(s)

AC124400, AI573415, BG085186, BY116790, CJ237327

Consensus CDS

CCDS26962.1

UniProtKB/Swiss-Prot

P50404

Related

ENSMUSP00000076383.4, ENSMUST00000077136.5

Conserved Domains (3) summary

cd03591
Location:261 → 374

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:45 → 102

Collagen; Collagen triple helix repeat (20 copies)

pfam09006
Location:223 → 267

Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization