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    Kansl2 KAT8 regulatory NSL complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 69612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kansl2provided by MGI
    Official Full Name
    KAT8 regulatory NSL complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1916862
    See related
    Ensembl:ENSMUSG00000022992 AllianceGenome:MGI:1916862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930009D17; 2310037I24Rik
    Summary
    Predicted to be involved in chromatin organization. Part of NSL complex. Is active in mitochondrion. Is expressed in nervous system and retina nuclear layer. Orthologous to human KANSL2 (KAT8 regulatory NSL complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.7), CNS E14 (RPKM 22.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kansl2 in Genome Data Viewer
    Location:
    15 F1; 15 54.52 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98415539..98432649, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98517658..98534770, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8611 Neighboring gene lactalbumin, alpha Neighboring gene olfactory receptor 278, pseudogene 1 Neighboring gene olfactory receptor family 11 subfamily M member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98341916-98342069 Neighboring gene STARR-seq mESC enhancer starr_39662 Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene microRNA 1291 Neighboring gene STARR-positive B cell enhancer ABC_E946 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene STARR-seq mESC enhancer starr_39663 Neighboring gene cyclin T1 Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene STARR-positive B cell enhancer ABC_E1917 Neighboring gene sperm microtubule inner protein 11 Neighboring gene adenylate cyclase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Pessoa Rodrigues C, et al. Sci Adv, 2020 May. PMID 32671208, Free PMC Article
    2. Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Gaub A, et al. Nat Commun, 2020 May 7. PMID 32382029, Free PMC Article
    3. The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Karoutas A, et al. Nat Cell Biol, 2019 Oct. PMID 31576060
    4. COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Guhathakurta S, et al. Nat Metab, 2023 Nov. PMID 37813994, Free PMC Article
    5. Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Sheikh BN, et al. Nat Cell Biol, 2020 Jul. PMID 32541879

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101985, MGC102368

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KAT8 regulatory NSL complex subunit 2
    Names
    NSL complex protein NSL2
    non-specific lethal 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289437.1 → NP_001276366.1  KAT8 regulatory NSL complex subunit 2 isoform b

      See identical proteins and their annotated locations for NP_001276366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK162714, BC083325, BI134551, CJ059354
      Consensus CDS
      CCDS88832.1
      UniProtKB/TrEMBL
      F8WJE3
      Related
      ENSMUSP00000112101.4, ENSMUST00000116400.4
      Conserved Domains (1) summary
      pfam13891
      Location:28 → 92
      zf-C3Hc3H; Potential DNA-binding domain

    2. NM_001289438.1 → NP_001276367.1  KAT8 regulatory NSL complex subunit 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC138221, AK046649, AK162714, BI134551, CJ059354
      UniProtKB/Swiss-Prot
      Q8BQR4
      Conserved Domains (1) summary
      pfam13891
      Location:173 → 230
      zf-C3Hc3H; Potential DNA-binding domain

    3. NM_001289439.1 → NP_001276368.1  KAT8 regulatory NSL complex subunit 2 isoform d

      See identical proteins and their annotated locations for NP_001276368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AK046649, AK162714, AK168499, BI134551, CJ059354
      UniProtKB/Swiss-Prot
      Q8BQR4
      Conserved Domains (1) summary
      pfam13891
      Location:112 → 169
      zf-C3Hc3H; Potential DNA-binding domain

    4. NM_001289440.1 → NP_001276369.1  KAT8 regulatory NSL complex subunit 2 isoform d

      See identical proteins and their annotated locations for NP_001276369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AK046649, AK162714, AK168499, BI134551, CJ059354
      UniProtKB/Swiss-Prot
      Q8BQR4
      Conserved Domains (1) summary
      pfam13891
      Location:112 → 169
      zf-C3Hc3H; Potential DNA-binding domain

    5. NM_001359827.1 → NP_001346756.1  KAT8 regulatory NSL complex subunit 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants 1 and 6 encode the same protein.
      Source sequence(s)
      AC138221
      Consensus CDS
      CCDS37190.1
      UniProtKB/Swiss-Prot
      Q3TJH8, Q569W7, Q5XJH6, Q8BQR4, Q8C8F3, Q8C8I6, Q8CEY3, Q99LE5
      UniProtKB/TrEMBL
      F8WJE3
      Conserved Domains (1) summary
      pfam13891
      Location:28 → 92
      zf-C3Hc3H; Potential DNA-binding domain

    6. NM_133714.5 → NP_598475.2  KAT8 regulatory NSL complex subunit 2 isoform a

      See identical proteins and their annotated locations for NP_598475.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 6 encode the same protein.
      Source sequence(s)
      AK046649, AK162714, BI134551, CJ059354
      Consensus CDS
      CCDS37190.1
      UniProtKB/Swiss-Prot
      Q3TJH8, Q569W7, Q5XJH6, Q8BQR4, Q8C8F3, Q8C8I6, Q8CEY3, Q99LE5
      UniProtKB/TrEMBL
      F8WJE3
      Related
      ENSMUSP00000155089.2, ENSMUST00000230542.2
      Conserved Domains (1) summary
      pfam13891
      Location:28 → 92
      zf-C3Hc3H; Potential DNA-binding domain

    RNA

    1. NR_153345.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC138221, AEKQ02119723

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98415539..98432649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316743.3 → XP_017172232.1  KAT8 regulatory NSL complex subunit 2 isoform X4

      Conserved Domains (1) summary
      pfam13891
      Location:112 → 169
      zf-C3Hc3H; Potential DNA-binding domain

    2. XM_036159568.1 → XP_036015461.1  KAT8 regulatory NSL complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      F8WJE3
      Conserved Domains (1) summary
      pfam13891
      Location:28 → 92
      zf-C3Hc3H; Potential DNA-binding domain

    3. XM_030248754.2 → XP_030104614.1  KAT8 regulatory NSL complex subunit 2 isoform X3

      Conserved Domains (1) summary
      pfam13891
      Location:173 → 230
      zf-C3Hc3H; Potential DNA-binding domain

    4. XM_030248755.2 → XP_030104615.1  KAT8 regulatory NSL complex subunit 2 isoform X4

      Conserved Domains (1) summary
      pfam13891
      Location:112 → 169
      zf-C3Hc3H; Potential DNA-binding domain

    5. XM_036159569.1 → XP_036015462.1  KAT8 regulatory NSL complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      F8WJE3
      Conserved Domains (1) summary
      pfam13891
      Location:28 → 92
      zf-C3Hc3H; Potential DNA-binding domain

    6. XM_030248753.2 → XP_030104613.1  KAT8 regulatory NSL complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      F8WJE3
      Conserved Domains (1) summary
      pfam13891
      Location:28 → 92
      zf-C3Hc3H; Potential DNA-binding domain

    RNA

    1. XR_384040.5 RNA Sequence

    2. XR_004938869.1 RNA Sequence

    3. XR_003951435.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQR4.1 GenPept UniProtKB/Swiss-Prot:Q8BQR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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