Shank1 SH3 and multiple ankyrin repeat domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shank1provided by MGI
Official Full Name: SH3 and multiple ankyrin repeat domains 1provided by MGI
Primary source: MGI:MGI:3613677
See related: Ensembl:ENSMUSG00000038738 AllianceGenome:MGI:3613677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. A structural constituent of postsynaptic density. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and regulation of signal transduction. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in dendritic spine; excitatory synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex; frontal cortex; and neocortex region. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 16.9), cortex adult (RPKM 13.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.83 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43958343..44009518)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44308916..44360094)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice.
Title: Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice.
A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.
Title: A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.
Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons.
Title: Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons.
Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice.
Title: Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice.
SHANK1 plays a role in neocortical learning-induced dendritic spine plasticity underlying learning and normal cognition; and in mechanisms mediating abnormalities of impaired cognition.
Title: Neocortical SHANK1 regulation of forebrain dependent associative learning.
A review: Shank1 knockout mouse model for autism spectrum disorder (ASD) displays moderate impairments in (I) social behavior, (II) communication, and (III) repetitive and stereotyped patterns of behavior, together with (IV) aberrant cognitive phenotypes, consistent with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions.
Title: Behavioral phenotypes and neurobiological mechanisms in the Shank1 mouse model for autism spectrum disorder: A translational perspective.
Study demonstrates that SHANK1 is developmentally expressed in hippocampal neurons and glial cells. Although the specific role for this developmental expression pattern in these different cell types is not fully understood, the current study provides the first developmental cell-type-specific expression profile.
Title: SHANK1 is differentially expressed during development in CA1 hippocampal neurons and astrocytes.
Expression of SHANK genes is a key component of autism spectrum disorder-associated pathways as the protein products are enriched in the postsynaptic density (PSD) of glutamatergic neurons.
Title: Early communication deficits in the Shank1 knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context.
The findings of this study indicated that Shank1 deletions lead to an aberrant cognitive phenotype characterized by severe impairments in object recognition memory and increased hippocampal BDNF levels, possibly due to epigenetic modifications.
Title: Aberrant cognitive phenotypes and altered hippocampal BDNF expression related to epigenetic modifications in mice lacking the post-synaptic scaffolding protein SHANK1: Implications for autism spectrum disorder.
"reduction of PV(+) neurons" was in all cases, i.e., in PV+/-, Shank1-/- and Shank3B-/- mice, was due to a reduction in Pvalb mRNA and PV protein
Title: Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Shank1 (e-PCR), detects polymorphism
- UniSTS:496555

RH137039 (e-PCR)
- UniSTS:219128

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables ankyrin repeat binding	ISO Inferred from Sequence Orthology more info
enables ankyrin repeat binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables somatostatin receptor binding	ISO Inferred from Sequence Orthology more info
enables somatostatin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
enables synaptic receptor adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables synaptic receptor adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables synaptic receptor adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of affect	IEA Inferred from Electronic Annotation more info
involved_in determination of affect	ISO Inferred from Sequence Orthology more info
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of AMPA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in righting reflex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in synapse maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SH3 and multiple ankyrin repeat domains protein 1

Names: SH3/ankyrin domain gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034115.1 → NP_001029287.1 SH3 and multiple ankyrin repeat domains protein 1

See identical proteins and their annotated locations for NP_001029287.1

Status: VALIDATED

Source sequence(s)

AC152939

Consensus CDS

CCDS52229.1

UniProtKB/Swiss-Prot

D3YZU1

Related

ENSMUSP00000103571.2, ENSMUST00000107938.8

Conserved Domains (8) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd09506
Location:2100 → 2165

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:947 → 1156

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:661 → 754

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43958343..44009518

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540864.5 → XP_006540927.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X1

See identical proteins and their annotated locations for XP_006540927.1

UniProtKB/Swiss-Prot

D3YZU1

Conserved Domains (8) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd09506
Location:2100 → 2165

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:947 → 1156

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:661 → 754

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_006540868.5 → XP_006540931.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X8

Conserved Domains (7) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:947 → 1156

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:661 → 754

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_006540867.5 → XP_006540930.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X7

Conserved Domains (7) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:947 → 1156

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:661 → 754

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_036153110.1 → XP_036009003.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X5

Conserved Domains (8) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd09506
Location:2065 → 2130

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:912 → 1121

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:661 → 754

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_006540865.5 → XP_006540928.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X2

UniProtKB/TrEMBL

D3YZU4

Related

ENSMUSP00000103568.2, ENSMUST00000107935.8

Conserved Domains (8) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd09506
Location:2092 → 2157

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:939 → 1148

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:661 → 754

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_006540866.5 → XP_006540929.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X3

UniProtKB/TrEMBL

D3YZU5

Related

ENSMUSP00000103567.2, ENSMUST00000107934.2

Conserved Domains (8) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd09506
Location:2091 → 2156

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:938 → 1147

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:652 → 745

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_030242576.2 → XP_030098436.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X4

Conserved Domains (8) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd09506
Location:2083 → 2148

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:930 → 1139

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:652 → 745

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_036153111.1 → XP_036009004.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X6

Conserved Domains (8) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd09506
Location:2056 → 2121

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:903 → 1112

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:652 → 745

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_030242575.2 → XP_030098435.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X1

UniProtKB/Swiss-Prot

D3YZU1

Conserved Domains (8) summary

PTZ00322
Location:333 → 468

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd09506
Location:2100 → 2165

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03095
Location:174 → 392

PHA03095; ankyrin-like protein; Provisional

PRK07764
Location:947 → 1156

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:661 → 754

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:279 → 311

ANK; ANK repeat [structural motif]

cd17175
Location:70 → 158

FERM_F0_SHANK1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 1 (SHANK1)

cl17036
Location:557 → 608

SH3; Src Homology 3 domain superfamily
XM_006540874.3 → XP_006540937.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X15

Conserved Domains (3) summary

cd09506
Location:1450 → 1515

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:297 → 506

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:51 → 104

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006540872.3 → XP_006540935.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X13

Conserved Domains (3) summary

cd09506
Location:1486 → 1551

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:333 → 542

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:47 → 140

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_030242578.2 → XP_030098438.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X14

Conserved Domains (3) summary

cd09506
Location:1478 → 1543

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:325 → 534

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:47 → 140

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006540869.4 → XP_006540932.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X9

Conserved Domains (3) summary

cd09506
Location:1578 → 1643

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:425 → 634

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:179 → 232

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036153113.1 → XP_036009006.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X12

Conserved Domains (3) summary

cd09506
Location:1529 → 1594

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:376 → 585

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:130 → 183

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036153112.1 → XP_036009005.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X9

Conserved Domains (3) summary

cd09506
Location:1578 → 1643

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:425 → 634

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:179 → 232

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006540870.4 → XP_006540933.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X10

Conserved Domains (3) summary

cd09506
Location:1562 → 1627

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:409 → 618

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:150 → 216

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006540871.4 → XP_006540934.3 SH3 and multiple ankyrin repeat domains protein 1 isoform X11

Conserved Domains (3) summary

cd09506
Location:1552 → 1617

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:399 → 608

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:113 → 206

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006540876.5 → XP_006540939.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X17

Conserved Domains (2) summary

cd09506
Location:1208 → 1273

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:55 → 264

PRK07764; DNA polymerase III subunits gamma and tau; Validated
XM_006540875.5 → XP_006540938.1 SH3 and multiple ankyrin repeat domains protein 1 isoform X16

Conserved Domains (2) summary

cd09506
Location:1243 → 1308

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PRK07764
Location:90 → 299

PRK07764; DNA polymerase III subunits gamma and tau; Validated