Zbtb49 zinc finger and BTB domain containing 49 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb49provided by MGI
Official Full Name: zinc finger and BTB domain containing 49provided by MGI
Primary source: MGI:MGI:1922329
See related: Ensembl:ENSMUSG00000029127 AllianceGenome:MGI:1922329
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp509; Znf509; 4930518A03Rik
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Predicted to be involved in several processes, including negative regulation of cell population proliferation; regulation of cytokine production; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; microtubule cytoskeleton; and nucleus. Predicted to be active in nucleoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to human ZBTB49 (zinc finger and BTB domain containing 49). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 2.7), whole brain E14.5 (RPKM 2.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 20.25 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (38347076..38377798, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (38189732..38220499, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 49

Names: zinc finger protein 509

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359466.2 → NP_001346395.1 zinc finger and BTB domain-containing protein 49 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC115931

Conserved Domains (2) summary

COG5048
Location:78 → 235

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:160 → 180

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001401384.1 → NP_001388313.1 zinc finger and BTB domain-containing protein 49 isoform 3

Status: VALIDATED

Source sequence(s)

AC115931

UniProtKB/TrEMBL

E9Q2Y5, Q8BLJ1

Related

ENSMUSP00000109748.2, ENSMUST00000114113.3
NM_001401385.1 → NP_001388314.1 zinc finger and BTB domain-containing protein 49 isoform 4

Status: VALIDATED

Source sequence(s)

AC115931
NM_029162.4 → NP_083438.1 zinc finger and BTB domain-containing protein 49 isoform 1

See identical proteins and their annotated locations for NP_083438.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC115931

Consensus CDS

CCDS19252.1

UniProtKB/Swiss-Prot

Q8BXX2, Q8CID4, Q8K2Z6

Related

ENSMUSP00000092429.4, ENSMUST00000094833.10

Conserved Domains (6) summary

smart00225
Location:26 → 119

BTB; Broad-Complex, Tramtrack and Bric a brac

COG5048
Location:376 → 576

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:500 → 520

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:386 → 408

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:15 → 118

BTB; BTB/POZ domain

pfam13465
Location:540 → 565

zf-H2C2_2; Zinc-finger double domain

RNA

NR_153116.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC115931

Related

ENSMUST00000143436.8
NR_174700.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC115931

Related

ENSMUST00000126267.8
NR_174701.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC115931
NR_174702.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC115931

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

38347076..38377798 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504163.4 → XP_006504226.1 zinc finger and BTB domain-containing protein 49 isoform X1

Conserved Domains (4) summary

PHA03247
Location:118 → 383

PHA03247; large tegument protein UL36; Provisional

COG5048
Location:375 → 536

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:388 → 408

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18233
Location:7 → 118

BTB_POZ_ZBTB49; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49)
XM_036165570.1 → XP_036021463.1 zinc finger and BTB domain-containing protein 49 isoform X3

Conserved Domains (2) summary

COG5048
Location:20 → 183

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:108 → 128

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036165571.1 → XP_036021464.1 zinc finger and BTB domain-containing protein 49 isoform X5

Conserved Domains (2) summary

COG5048
Location:1 → 151

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:76 → 96

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011240780.3 → XP_011239082.1 zinc finger and BTB domain-containing protein 49 isoform X2

UniProtKB/TrEMBL

D6RGS0

Conserved Domains (4) summary

PHA03247
Location:118 → 383

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:388 → 408

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:386 → 408

zf-C2H2; Zinc finger, C2H2 type

cd18233
Location:7 → 118

BTB_POZ_ZBTB49; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49)