Tnxb tenascin XB [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnxbprovided by MGI
Official Full Name: tenascin XBprovided by MGI
Primary source: MGI:MGI:1932137
See related: Ensembl:ENSMUSG00000033327 AllianceGenome:MGI:1932137
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tnx; Tn-mhc
Summary: Enables collagen binding activity and heparin binding activity. Acts upstream of or within several processes, including collagen fibril organization; regulation of JUN kinase activity; and triglyceride metabolic process. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; heart and pericardium; and immune system. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and vesicoureteral reflux. Orthologous to human TNXB (tenascin XB). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 40.0), mammary gland adult (RPKM 37.6) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.24 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34879427..34938789)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34660453..34719815)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling.
Title: Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling.
Loss of Smooth Muscle Tenascin-X Inhibits Vascular Remodeling Through Increased TGF-beta Signaling.
Title: Loss of Smooth Muscle Tenascin-X Inhibits Vascular Remodeling Through Increased TGF-β Signaling.
Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
Title: Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice.
Title: Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice.
Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome.
Title: Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome.
TNX-deficient mice have accelerated gastric emptying and hypersensitivity of gastric vagal mechanoreceptors.
Title: A novel role for the extracellular matrix glycoprotein-Tenascin-X in gastric function.
This study found significant bone loss and upregulation of osteoclast marker gene expression in TNX-deficient mice.
Title: TNX deficiency results in bone loss due to an increase in multinucleated osteoclasts.
Tnx gene expression contributes to promoting TGFbeta1 mRNA expression in ocular fibroblasts and VEGF-A in macrophages, macrophage invasion, up-regulation of VEGF-A expression and neovascularization in an injured corneal stroma.
Title: Loss of tenascin X gene function impairs injury-induced stromal angiogenesis in mouse corneas.
these wound healing-related properties are affected in a TNX-deficient extracellular environment
Title: Wound healing-related properties detected in an experimental model with a collagen gel contraction assay are affected in the absence of tenascin-X.
Results suggest that tenascin-X secreted from Schwann cells and/or fibroblasts is involved in blood vessel formation in peripheral nerves.
Title: A potential contribution of tenascin-X to blood vessel formation in peripheral nerves.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables collagen fibril binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in elastic fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within phospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of collagen fibril organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tenascin-X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428336.1 → NP_001415265.1 tenascin-X isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CT009767, CT573030

UniProtKB/TrEMBL

O54796
NM_031176.3 → NP_112453.2 tenascin-X isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CT009767, CT573030

Consensus CDS

CCDS28656.2

UniProtKB/TrEMBL

E9Q2T3, Q3V5L4

Related

ENSMUSP00000127487.2, ENSMUST00000168533.8

Conserved Domains (4) summary

cd00063
Location:2641 → 2720

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1945 → 2025

fn3; Fibronectin type III domain

pfam00147
Location:2908 → 3117

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:389 → 417

EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34879427..34938789

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525185.5 → XP_006525248.1 tenascin-X isoform X1

Conserved Domains (6) summary

cd00063
Location:1386 → 1466

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:4143 → 4352

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:389 → 417

EGF_2; EGF-like domain

pfam00041
Location:3875 → 3953

fn3; Fibronectin type III domain

pfam01414
Location:498 → 541

DSL; Delta serrate ligand

pfam18720
Location:298 → 325

EGF_Tenascin; Tenascin EGF domain
XM_006525191.5 → XP_006525254.1 tenascin-X isoform X7

See identical proteins and their annotated locations for XP_006525254.1

UniProtKB/TrEMBL

O35452

Conserved Domains (6) summary

cd00063
Location:1386 → 1466

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:3700 → 3909

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:389 → 417

EGF_2; EGF-like domain

pfam00041
Location:3432 → 3510

fn3; Fibronectin type III domain

pfam01414
Location:498 → 541

DSL; Delta serrate ligand

pfam18720
Location:298 → 325

EGF_Tenascin; Tenascin EGF domain
XM_006525186.5 → XP_006525249.1 tenascin-X isoform X2

See identical proteins and their annotated locations for XP_006525249.1

UniProtKB/TrEMBL

A0A5F8MPH8, O54796

Related

ENSMUSP00000158977.2, ENSMUST00000238967.2

Conserved Domains (6) summary

cd00063
Location:1386 → 1466

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:4138 → 4347

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:389 → 417

EGF_2; EGF-like domain

pfam00041
Location:3870 → 3948

fn3; Fibronectin type III domain

pfam01414
Location:498 → 541

DSL; Delta serrate ligand

pfam18720
Location:298 → 325

EGF_Tenascin; Tenascin EGF domain
XM_006525187.5 → XP_006525250.1 tenascin-X isoform X3

See identical proteins and their annotated locations for XP_006525250.1

UniProtKB/TrEMBL

O54796

Conserved Domains (6) summary

cd00063
Location:1263 → 1343

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:4020 → 4229

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:389 → 417

EGF_2; EGF-like domain

pfam00041
Location:3752 → 3830

fn3; Fibronectin type III domain

pfam01414
Location:498 → 541

DSL; Delta serrate ligand

pfam18720
Location:298 → 325

EGF_Tenascin; Tenascin EGF domain
XM_036160855.1 → XP_036016748.1 tenascin-X isoform X5

UniProtKB/TrEMBL

A0A571BG59, O54796

Related

ENSMUSP00000158703.2, ENSMUST00000238305.2

Conserved Domains (5) summary

cd00063
Location:3629 → 3708

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:706 → 732

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:2068 → 2148

fn3; Fibronectin type III domain

pfam00147
Location:3896 → 4105

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

NF033759
Location:160 → 557

exchanger_TraA; outer membrane exchange protein TraA
XM_036160854.1 → XP_036016747.1 tenascin-X isoform X4

UniProtKB/TrEMBL

O54796

Conserved Domains (5) summary

cd00063
Location:3634 → 3713

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:706 → 732

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:2073 → 2153

fn3; Fibronectin type III domain

pfam00147
Location:3901 → 4110

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

NF033759
Location:160 → 557

exchanger_TraA; outer membrane exchange protein TraA
XM_006525189.5 → XP_006525252.1 tenascin-X isoform X6

See identical proteins and their annotated locations for XP_006525252.1

UniProtKB/TrEMBL

O54796

Conserved Domains (6) summary

cd00063
Location:1021 → 1101

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00147
Location:3778 → 3987

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:389 → 417

EGF_2; EGF-like domain

pfam00041
Location:3510 → 3588

fn3; Fibronectin type III domain

pfam01414
Location:498 → 541

DSL; Delta serrate ligand

pfam18720
Location:298 → 325

EGF_Tenascin; Tenascin EGF domain