Igbp1 immunoglobulin (CD79A) binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igbp1provided by MGI
Official Full Name: immunoglobulin (CD79A) binding protein 1provided by MGI
Primary source: MGI:MGI:1346500
See related: Ensembl:ENSMUSG00000031221 AllianceGenome:MGI:1346500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p52; Pc52; Tap42
Summary: Enables mitogen-activated protein kinase kinase binding activity and protein domain specific binding activity. Involved in positive regulation of dephosphorylation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in cytoplasm and microtubule. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome. Orthologous to several human genes including IGBP1 (immunoglobulin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 27.3), placenta adult (RPKM 25.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X C3; X 43.72 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (99537897..99559731)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (100494291..100516125)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report the significance and altered activity of the type 2A protein phosphatase-alpha4 complex in healthy and hypertrophied myocardium.
Title: Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy.
both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation.
Title: The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.
Alpha4 (Igbp1) plays a required role in regulating the assembly and maintenance of adaptive PP2A phosphatase complexes.
Title: Alpha4 is an essential regulator of PP2A phosphatase activity.
results show that alpha4, a noncatalytic subunit of protein phosphatase 2A, is required to repress apoptosis in murine cells
Title: The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.
alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6
Title: The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igbp1 (e-PCR), detects polymorphism
- UniSTS:527393

AI662457 (e-PCR)
- UniSTS:166188

AW208785 (e-PCR)
- UniSTS:181313

RH127075 (e-PCR)
- UniSTS:207810

RH135891 (e-PCR)
- UniSTS:209889

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: immunoglobulin-binding protein 1

Names: CD79a-binding protein 1; alpha 4; alpha4 phosphoprotein; lymphocyte signal transduction molecule alpha 4; phosphoprotein, component, 52 kDa; protein phosphatase 2/4/6 regulatory subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008784.3 → NP_032810.4 immunoglobulin-binding protein 1

Status: VALIDATED

Source sequence(s)

AK017166, BC056186, CX203560, DV654442

Consensus CDS

CCDS30302.1

UniProtKB/Swiss-Prot

Q61249

Related

ENSMUSP00000033570.6, ENSMUST00000033570.6

Conserved Domains (1) summary

pfam04177
Location:17 → 329

TAP42; TAP42-like family