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    Osbpl7 oxysterol binding protein-like 7 [ Mus musculus (house mouse) ]

    Gene ID: 71240, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Osbpl7provided by MGI
    Official Full Name
    oxysterol binding protein-like 7provided by MGI
    Primary source
    MGI:MGI:1918490
    See related
    Ensembl:ENSMUSG00000038534 AllianceGenome:MGI:1918490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933437E18Rik
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in cellular response to cholesterol and positive regulation of proteasomal protein catabolic process. Predicted to be located in autophagosome and nucleoplasm. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and lung. Orthologous to human OSBPL7 (oxysterol binding protein like 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 18.6), testis adult (RPKM 16.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osbpl7 in Genome Data Viewer
    Location:
    11 D; 11 60.75 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96941459..96959730)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97050633..97068904)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E909 Neighboring gene leucine rich repeat containing 46 Neighboring gene predicted gene 11533 Neighboring gene STARR-positive B cell enhancer ABC_E8445 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene predicted gene, 51917 Neighboring gene microRNA 8103 Neighboring gene STARR-seq mESC enhancer starr_30581 Neighboring gene T-box 21 Neighboring gene STARR-positive B cell enhancer ABC_E8446 Neighboring gene TBK1 binding protein 1 Neighboring gene microRNA 7235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria. Duara J, et al. Am J Physiol Renal Physiol, 2024 Sep 1. PMID 38961844,
    2. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
    3. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria.
      Title: Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310509.2 → NP_001297438.2  oxysterol-binding protein-related protein 7

      Status: VALIDATED

      Source sequence(s)
      AK017095, AK171585, AL606664, BE990127, BY593908
      Consensus CDS
      CCDS79034.2
      UniProtKB/TrEMBL
      A2A716, Q3TAX1
      Related
      ENSMUSP00000087474.7, ENSMUST00000090020.13
      Conserved Domains (2) summary
      cd13287
      Location:27 → 149
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:473 → 814
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96941459..96959730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249264.2 → XP_011247566.1  oxysterol-binding protein-related protein 7 isoform X1

      Conserved Domains (2) summary
      cd13287
      Location:153 → 275
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:640 → 987
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_036156991.1 → XP_036012884.1  oxysterol-binding protein-related protein 7 isoform X3

      Conserved Domains (1) summary
      cd13287
      Location:153 → 275
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

    3. XM_036156990.1 → XP_036012883.1  oxysterol-binding protein-related protein 7 isoform X2

      Conserved Domains (2) summary
      pfam01237
      Location:372 → 719
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1 → 48
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_879739.2 RNA Sequence

    2. XR_003949505.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081434.1: Suppressed sequence

      Description
      NM_001081434.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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