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    Zfp469 zinc finger protein 469 [ Mus musculus (house mouse) ]

    Gene ID: 195209, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp469provided by MGI
    Official Full Name
    zinc finger protein 469provided by MGI
    Primary source
    MGI:MGI:2684868
    See related
    Ensembl:ENSMUSG00000043903 AllianceGenome:MGI:2684868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm22
    Summary
    Acts upstream of or within several processes, including extracellular matrix organization; fibroblast proliferation; and substantia propria of cornea development. Is expressed in several structures, including craniocervical region bone; sensory organ; skeleton; tarsus; and urinary system. Used to study brittle cornea syndrome 1. Human ortholog(s) of this gene implicated in brittle cornea syndrome 1. Orthologous to human ZNF469 (zinc finger protein 469). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 1.6), limb E14.5 (RPKM 1.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp469 in Genome Data Viewer
    Location:
    8 E1; 8 70.85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122770009..122999389)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122043123..122272650)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene BTG3 associated nuclear protein Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene microRNA 7237 Neighboring gene STARR-seq mESC enhancer starr_22941 Neighboring gene STARR-seq mESC enhancer starr_22942 Neighboring gene predicted gene, 34413 Neighboring gene predicted gene, 39268 Neighboring gene Zfpm1R1 and Zfpm1R2 erythroid cis-regulatory modules Neighboring gene STARR-positive B cell enhancer ABC_E8268 Neighboring gene Zfpm1R7 and Zfpm1R21 erythroid cis-regulatory modules Neighboring gene STARR-seq mESC enhancer starr_22944 Neighboring gene STARR-positive B cell enhancer ABC_E2277 Neighboring gene STARR-positive B cell enhancer ABC_E6695 Neighboring gene Zfpm1R13 and Zfpm1R24 erythroid cis-regulatory modules Neighboring gene STARR-positive B cell enhancer ABC_E6696 Neighboring gene Zfpm1R19 and Zfpm1R14 erythroid cis-regulatory modules Neighboring gene predicted gene, 39269 Neighboring gene STARR-seq mESC enhancer starr_22945 Neighboring gene Zfpm1R6 erythroid cis-regulatory module Neighboring gene zinc finger protein, multitype 1 Neighboring gene Zfpm1R18 erythroid cis-regulatory module Neighboring gene Zfpm1R10 erythroid cis-regulatory module Neighboring gene Zfpm1R12 erythroid cis-regulatory module Neighboring gene predicted gene, 46056

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two primate-specific small non-protein-coding RNAs in transgenic mice: neuronal expression, subcellular localization and binding partners. Khanam T, et al. Nucleic Acids Res, 2007. PMID 17175535, Free PMC Article
    2. A mouse model of brittle cornea syndrome caused by mutation in Zfp469. Stanton CM, et al. Dis Model Mech, 2021 Sep 1. PMID 34368841, Free PMC Article
    3. Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling. Aboudehen K, et al. J Biol Chem, 2018 Jun 15. PMID 29716997, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mouse model of brittle cornea syndrome caused by mutation in Zfp469.
      Title: A mouse model of brittle cornea syndrome caused by mutation in Zfp469.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression involved in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within substantia propria of cornea development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 469

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362883.2 → NP_001349812.1  zinc finger protein 469

      Status: VALIDATED

      Source sequence(s)
      AC121976
      Consensus CDS
      CCDS90472.1
      UniProtKB/TrEMBL
      A0A571BEL3
      Related
      ENSMUSP00000158621.2, ENSMUST00000187142.3
      Conserved Domains (3) summary
      PHA03247
      Location:3281 → 3701
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:3171 → 3191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:3171 → 3191
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      122770009..122999389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248576.4 → XP_011246878.1  zinc finger protein 469 isoform X1

      See identical proteins and their annotated locations for XP_011246878.1

      UniProtKB/TrEMBL
      A0A571BEL3
      Conserved Domains (3) summary
      PHA03247
      Location:3281 → 3701
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:3171 → 3191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:3171 → 3191
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_036153837.1 → XP_036009730.1  zinc finger protein 469 isoform X1

      UniProtKB/TrEMBL
      A0A571BEL3
      Conserved Domains (3) summary
      PHA03247
      Location:3281 → 3701
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:3171 → 3191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:3171 → 3191
      zf-C2H2; Zinc finger, C2H2 type

    3. XM_006531558.5 → XP_006531621.1  zinc finger protein 469 isoform X1

      See identical proteins and their annotated locations for XP_006531621.1

      UniProtKB/TrEMBL
      A0A571BEL3
      Conserved Domains (3) summary
      PHA03247
      Location:3281 → 3701
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:3171 → 3191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:3171 → 3191
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version

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