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    Tas1r2 taste receptor, type 1, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 83770, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tas1r2provided by MGI
    Official Full Name
    taste receptor, type 1, member 2provided by MGI
    Primary source
    MGI:MGI:1933546
    See related
    Ensembl:ENSMUSG00000028738 AllianceGenome:MGI:1933546
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TR2; T1r2; Gpr71
    Summary
    Enables sweet taste receptor activity. Acts upstream of or within sensory perception of sweet taste. Predicted to be part of sweet taste receptor complex. Predicted to be active in plasma membrane. Is expressed in tongue anterior part. Orthologous to human TAS1R2 (taste 1 receptor member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Tas1r2 in Genome Data Viewer
    Location:
    4 D3; 4 70.82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139380849..139397591)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139653538..139670280)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 2 Neighboring gene VISTA enhancer mm1506 Neighboring gene STARR-seq mESC enhancer starr_11836 Neighboring gene STARR-positive B cell enhancer ABC_E6246 Neighboring gene STARR-positive B cell enhancer ABC_E4694 Neighboring gene aldehyde dehydrogenase 4 family, member A1 Neighboring gene microRNA 7020 Neighboring gene predicted gene, 42334 Neighboring gene paired box 7 Neighboring gene STARR-seq mESC enhancer starr_11839 Neighboring gene STARR-seq mESC enhancer starr_11840 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:139369700-139369901 Neighboring gene predicted gene, 46873

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to sweet taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sweet taste receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to sweet taste receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to taste receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables taste receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of sweet taste receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of sweet taste receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of sweet taste receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    taste receptor type 1 member 2
    Names
    G-protein coupled receptor 71
    candidate taste receptor T1R2
    sweet taste receptor T1R2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031873.1NP_114079.1  taste receptor type 1 member 2 precursor

      See identical proteins and their annotated locations for NP_114079.1

      Status: PROVISIONAL

      Source sequence(s)
      AF337041
      Consensus CDS
      CCDS18849.1
      UniProtKB/Swiss-Prot
      B1AXX0, Q923J8, Q925I4
      UniProtKB/TrEMBL
      E9Q0R6
      Related
      ENSMUSP00000030510.8, ENSMUST00000030510.14
      Conserved Domains (4) summary
      pfam00003
      Location:581818
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:73458
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:496547
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:30487
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      139380849..139397591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)