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    Plch1 phospholipase C, eta 1 [ Mus musculus (house mouse) ]

    Gene ID: 269437, updated on 27-Nov-2024

    Summary

    Official Symbol
    Plch1provided by MGI
    Official Full Name
    phospholipase C, eta 1provided by MGI
    Primary source
    MGI:MGI:2683547
    See related
    Ensembl:ENSMUSG00000036834 AllianceGenome:MGI:2683547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plcl3; PLCeta1; PLC-eta-1
    Summary
    Predicted to enable calcium-dependent phospholipase C activity and phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Located in cytosol and membrane. Is expressed in intestine; musculoskeletal system; nervous system; and neural retina. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human PLCH1 (phospholipase C eta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 3.5), whole brain E14.5 (RPKM 2.2) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Plch1 in Genome Data Viewer
    Location:
    3 E1; 3 30.08 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63603620..63806929, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63696199..63899503, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34240 Neighboring gene STARR-seq mESC enhancer starr_07833 Neighboring gene small transmembrane regulator of ion transport 1 Neighboring gene STARR-seq mESC enhancer starr_07834 Neighboring gene STARR-seq mESC enhancer starr_07835 Neighboring gene STARR-seq mESC enhancer starr_07836 Neighboring gene STARR-seq mESC enhancer starr_07837 Neighboring gene RIKEN cDNA E130311K13 gene Neighboring gene predicted gene, 34379

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC57096

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
    Names
    phosphoinositide phospholipase C-eta-1
    phospholipase C-like protein 3
    NP_001171203.1
    NP_001171204.1
    NP_001357913.1
    NP_001357914.1
    NP_899014.2
    XP_006501593.1
    XP_006501594.1
    XP_006501596.1
    XP_006501598.1
    XP_006501599.1
    XP_006501601.1
    XP_006501604.1
    XP_011238433.1
    XP_011238435.1
    XP_011238436.1
    XP_017175082.1
    XP_017175083.1
    XP_017175084.1
    XP_017175085.1
    XP_017175087.1
    XP_017175088.1
    XP_017175089.1
    XP_017175090.1
    XP_030108492.1
    XP_030108493.1
    XP_036019019.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177732.2NP_001171203.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 3

      See identical proteins and their annotated locations for NP_001171203.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as PLC-eta1a) differs in the 3' UTR and includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. This results in an isoform (3, also known as phospholipase C-eta1a) that has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC116732, AC121285
      Consensus CDS
      CCDS57215.1
      UniProtKB/TrEMBL
      H3BKE1
      Related
      ENSMUSP00000124463.3, ENSMUST00000162269.9
      Conserved Domains (7) summary
      cd00275
      Location:732856
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298702
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd00051
      Location:146212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:227298
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:147208
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:441542
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:22128
      PH-like; Pleckstrin homology-like domain
    2. NM_001177733.2NP_001171204.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 2

      See identical proteins and their annotated locations for NP_001171204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as PLC-eta1b) includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. This results in an isoform (2, also known as phospholipase C-eta1b) that has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC116732, AC121285
      Consensus CDS
      CCDS50918.1
      UniProtKB/TrEMBL
      H3BKE1
      Related
      ENSMUSP00000124632.3, ENSMUST00000159676.9
      Conserved Domains (7) summary
      cd00275
      Location:732856
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298702
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd00051
      Location:146212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:227298
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:147208
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:441542
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:22128
      PH-like; Pleckstrin homology-like domain
    3. NM_001370984.1NP_001357913.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116732, AC121285
      UniProtKB/TrEMBL
      I1E4X4
      Conserved Domains (4) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    4. NM_001370985.1NP_001357914.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116732, AC121285
      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:731855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298701
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:146175
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:146286
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:22128
      PH-like; Pleckstrin homology-like domain
    5. NM_183191.4NP_899014.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 1

      See identical proteins and their annotated locations for NP_899014.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as PLC-eta1c) encodes the longest isoform (1, also known as phospholipase C-eta1c).
      Source sequence(s)
      AC116732, AC121285
      Consensus CDS
      CCDS38444.2
      UniProtKB/Swiss-Prot
      Q4KWH5, Q4KWH6, Q4KWH7, Q69ZS3, Q7TPQ1, Q8CFQ2
      UniProtKB/TrEMBL
      I1E4X6
      Related
      ENSMUSP00000081122.6, ENSMUST00000084105.12
      Conserved Domains (7) summary
      cd00275
      Location:732856
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298702
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd00051
      Location:146212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:227298
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:147208
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:441542
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:22128
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      63603620..63806929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252633.2XP_030108493.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X10

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    2. XM_006501541.5XP_006501604.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    3. XM_017319596.3XP_017175085.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    4. XM_006501536.5XP_006501599.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    5. XM_006501533.5XP_006501596.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_006501596.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    6. XM_017319595.3XP_017175084.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:690814
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310660
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    7. XM_006501535.5XP_006501598.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    8. XM_006501530.5XP_006501593.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_006501593.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    9. XM_011240131.4XP_011238433.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_011238433.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    10. XM_017319593.3XP_017175082.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    11. XM_006501531.5XP_006501594.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_006501594.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    12. XM_017319594.1XP_017175083.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    13. XM_011240134.3XP_011238436.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

      See identical proteins and their annotated locations for XP_011238436.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (2) summary
      cd08632
      Location:115519
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:44659
      PLN02228; Phosphoinositide phospholipase C
    14. XM_011240133.3XP_011238435.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

      See identical proteins and their annotated locations for XP_011238435.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (2) summary
      cd08632
      Location:115519
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:44659
      PLN02228; Phosphoinositide phospholipase C
    15. XM_017319600.3XP_017175089.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X13

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02230
      Location:285853
      PLN02230; phosphoinositide phospholipase C 4
      cd15898
      Location:158187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    16. XM_017319601.3XP_017175090.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X14

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    17. XM_017319599.3XP_017175088.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X12

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    18. XM_006501538.5XP_006501601.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

      UniProtKB/TrEMBL
      H3BKK4, I1E4X4
      Related
      ENSMUSP00000135424.2, ENSMUST00000177143.8
      Conserved Domains (4) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    19. XM_017319598.3XP_017175087.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X11

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    20. XM_036163126.1XP_036019019.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X15

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain
    21. XM_030252632.2XP_030108492.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

      UniProtKB/TrEMBL
      I1E4X4
      Conserved Domains (4) summary
      cd00275
      Location:743867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34140
      PH-like; Pleckstrin homology-like domain