Peli2 pellino 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Peli2provided by MGI
Official Full Name: pellino 2provided by MGI
Primary source: MGI:MGI:1891445
See related: Ensembl:ENSMUSG00000021846 AllianceGenome:MGI:1891445
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables protein-macromolecule adaptor activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Located in cytosol and membrane. Is expressed in several structures, including neural tube; notochord; sensory organ; skeleton; and thymus. Orthologous to human PELI2 (pellino E3 ubiquitin protein ligase family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 16.4), ovary adult (RPKM 8.7) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 24.6 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (48358096..48519035)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (48120777..48281578)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pellino2 accelerate inflammation and pyroptosis via the ubiquitination and activation of NLRP3 inflammation in model of pediatric pneumonia.
Title: Pellino2 accelerate inflammation and pyroptosis via the ubiquitination and activation of NLRP3 inflammation in model of pediatric pneumonia.
Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway.
Title: Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway.
Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2.
Title: Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2.
The functions of Pellino2 in the NLRP3 pathway are dependent on Pellino2 FHA and RING-like domains, with Pellino2 promoting the ubiquitination of NLRP3 during the priming phase of activation.
Title: The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome.
Pellino 2 plays a critical role for TLR/IL-1R-mediated post-transcriptional control.
Title: Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control.
Pellino-2 is a tissue-restricted component of a signaling pathway that couples the mouse pelle-like kinase/IL-1 receptor-associated kinase protein to IL-1- or lipopolysaccharide-dependent signaling.
Title: Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Peli2 (e-PCR), detects polymorphism
- UniSTS:226085

08.MMHAP27FRC8.seq (e-PCR)
- UniSTS:122926

BB084638 (e-PCR)
- UniSTS:209038

BB129927 (e-PCR)
- UniSTS:186002

AW047589 (e-PCR)
- UniSTS:180642

RH136165 (e-PCR)
- UniSTS:210160

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of Toll signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase pellino homolog 2

Names: RING-type E3 ubiquitin transferase pellino homolog 2; protein pellino homolog 2

NP_001411702.1

EC 2.3.2.27

NP_291080.2

EC 2.3.2.27

XP_011243533.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424773.1 → NP_001411702.1 E3 ubiquitin-protein ligase pellino homolog 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC154528, AC174647

UniProtKB/TrEMBL

A0A2I3BRM8

Related

ENSMUSP00000154661.2, ENSMUST00000227362.2
NM_033602.3 → NP_291080.2 E3 ubiquitin-protein ligase pellino homolog 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC154528, AC174647

Consensus CDS

CCDS36901.1

UniProtKB/Swiss-Prot

Q8BST6, Q8C4F2, Q8CC65, Q8R2X4, Q9ERJ7

UniProtKB/TrEMBL

E9QPQ6

Related

ENSMUSP00000072894.5, ENSMUST00000073150.6

Conserved Domains (1) summary

pfam04710
Location:12 → 419

Pellino; Pellino

RNA

NR_188927.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154528, AC174647
NR_188928.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154528, AC174647
NR_188929.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154528, AC174647

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

48358096..48519035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245231.3 → XP_011243533.1 E3 ubiquitin-protein ligase pellino homolog 2 isoform X4

Conserved Domains (1) summary

pfam04710
Location:10 → 231

Pellino