Wdpcp WD repeat containing planar cell polarity effector [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdpcpprovided by MGI
Official Full Name: WD repeat containing planar cell polarity effectorprovided by MGI
Primary source: MGI:MGI:2144467
See related: Ensembl:ENSMUSG00000020319 AllianceGenome:MGI:2144467
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Frtz; homolog-13
Summary: Enables phosphatidylinositol binding activity. Acts upstream of or within several processes, including embryonic digit morphogenesis; podocyte cell migration; and sensory organ morphogenesis. Located in axonemal basal plate. Is expressed in several structures, including alimentary system epithelium; brain; musculoskeletal system; nose; and respiratory system. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 15 and congenital heart defects, hamartomas of tongue, and polysyndactyly. Orthologous to human WDPCP (WD repeat containing planar cell polarity effector). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in cerebellum adult (RPKM 9.9), testis adult (RPKM 7.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.1; 11 13.9 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (21521969..21848686)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (21571969..21898687)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling.
Title: Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling.
Data suggest that the WD repeat containing planar cell polarity effector (Wdpcp) mutant mice will be a useful tool to dissect the molecular mechanisms that govern the remodeling of the primitive plexus during coronary development.
Title: Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling.
Wdpcp is required for Sept2 recruitment to actin filaments.
Title: Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

AI449204 (e-PCR)
- UniSTS:160581

15.MMHAP28FLE3.seq (e-PCR)
- UniSTS:123257

D11Hjk27 (e-PCR), detects polymorphism
- UniSTS:471185

D11Hjk28 (e-PCR), detects polymorphism
- UniSTS:471186

D11Hjk29 (e-PCR), detects polymorphism
- UniSTS:471187

AV249152 (e-PCR)
- UniSTS:180162

D11Mit371 (e-PCR), detects polymorphism
- UniSTS:141770

NoName (e-PCR)
- UniSTS:236528

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of planar polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in establishment of protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within podocyte cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cilium assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of embryonic cell shape	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tongue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axonemal basal plate	IBA Inferred from Biological aspect of Ancestor more info
located_in axonemal basal plate	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat-containing and planar cell polarity effector protein fritz homolog

Names: WD repeat-containing protein C2orf86 homolog; mFrtz

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364768.1 → NP_001351697.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 2

Status: VALIDATED

Source sequence(s)

AK043672, AK083042

Conserved Domains (2) summary

sd00039
Location:231 → 266

7WD40; WD40 repeat [structural motif]

pfam11768
Location:1 → 512

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
NM_145425.3 → NP_663400.2 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 1

Status: VALIDATED

Source sequence(s)

AK083042

Consensus CDS

CCDS24467.1

UniProtKB/Swiss-Prot

Q8BRR5, Q8C456, Q91ZJ2

UniProtKB/TrEMBL

B1ATJ7

Related

ENSMUSP00000020568.4, ENSMUST00000020568.10

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

21521969..21848686

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514636.4 → XP_006514699.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_030245786.2 → XP_030101646.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X7

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_011243680.4 → XP_011241982.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_017314434.3 → XP_017169923.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_006514635.5 → XP_006514698.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_036156519.1 → XP_036012412.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X4

UniProtKB/Swiss-Prot

Q8BRR5, Q8C456, Q91ZJ2

UniProtKB/TrEMBL

B1ATJ7

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_006514631.5 → XP_006514694.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X1

Conserved Domains (2) summary

sd00039
Location:332 → 367

7WD40; WD40 repeat [structural motif]

pfam11768
Location:70 → 613

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_006514638.5 → XP_006514701.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X3

Conserved Domains (2) summary

sd00039
Location:332 → 367

7WD40; WD40 repeat [structural motif]

pfam11768
Location:70 → 613

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_017314435.3 → XP_017169924.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X6

Conserved Domains (2) summary

sd00039
Location:332 → 367

7WD40; WD40 repeat [structural motif]

pfam11768
Location:70 → 613

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_036156518.1 → XP_036012411.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_030245783.2 → XP_030101643.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_030245784.2 → XP_030101644.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X4

UniProtKB/Swiss-Prot

Q8BRR5, Q8C456, Q91ZJ2

UniProtKB/TrEMBL

B1ATJ7

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_030245785.2 → XP_030101645.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X5

Conserved Domains (2) summary

sd00039
Location:231 → 266

7WD40; WD40 repeat [structural motif]

pfam11768
Location:1 → 512

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_006514632.5 → XP_006514695.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X1

Conserved Domains (2) summary

sd00039
Location:332 → 367

7WD40; WD40 repeat [structural motif]

pfam11768
Location:70 → 613

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_006514637.5 → XP_006514700.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 591

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_036156520.1 → XP_036012413.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X5

Conserved Domains (2) summary

sd00039
Location:231 → 266

7WD40; WD40 repeat [structural motif]

pfam11768
Location:1 → 512

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_036156522.1 → XP_036012415.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X10

Conserved Domains (2) summary

sd00039
Location:131 → 166

7WD40; WD40 repeat [structural motif]

pfam11768
Location:2 → 412

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_030245787.2 → XP_030101647.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X10

Conserved Domains (2) summary

sd00039
Location:131 → 166

7WD40; WD40 repeat [structural motif]

pfam11768
Location:2 → 412

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_006514641.5 → XP_006514704.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X8

Conserved Domains (2) summary

sd00039
Location:332 → 367

7WD40; WD40 repeat [structural motif]

pfam11768
Location:70 → 595

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_036156521.1 → XP_036012414.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X9

Conserved Domains (2) summary

sd00039
Location:332 → 367

7WD40; WD40 repeat [structural motif]

pfam11768
Location:70 → 595

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz