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    Hsp90b1 heat shock protein 90, beta (Grp94), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 22027, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hsp90b1provided by MGI
    Official Full Name
    heat shock protein 90, beta (Grp94), member 1provided by MGI
    Primary source
    MGI:MGI:98817
    See related
    Ensembl:ENSMUSG00000020048 AllianceGenome:MGI:98817
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TA-3; Tra1; gp96; ERp99; GRP94; Targ2; Tra-1; endoplasmin
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in ERAD pathway; insulin processing; and protein folding. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Located in endoplasmic reticulum and sperm plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including central nervous system; heart; metanephros; pancreas; and respiratory system. Used to study male infertility due to globozoospermia. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in placenta adult (RPKM 303.0), CNS E11.5 (RPKM 168.9) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Hsp90b1 in Genome Data Viewer
    Location:
    10 C1; 10 43.05 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (86526705..86541308, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86690841..86705444, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5174 Neighboring gene STARR-seq mESC enhancer starr_27466 Neighboring gene RIKEN cDNA 1810014B01 gene Neighboring gene STARR-seq mESC enhancer starr_27467 Neighboring gene tetratricopeptide repeat domain 41 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:86190323-86190623 Neighboring gene STARR-positive B cell enhancer ABC_E11451 Neighboring gene fatty acid binding protein 3, muscle and heart, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_27469 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86240990-86241290 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86241543-86241844 Neighboring gene 5'-nucleotidase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E8356

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent protein folding chaperone  
    enables RNA binding  
    enables RNA binding  
    enables low-density lipoprotein particle receptor binding PubMed 
    enables protein binding PubMed 
    enables protein folding chaperone PubMed 
    enables protein phosphatase binding PubMed 
    enables protein phosphatase inhibitor activity PubMed 
    enables unfolded protein binding  
    enables unfolded protein binding  
    Process Evidence Code Pubs
    involved_in ERAD pathway  
    involved_in ERAD pathway  
    acts_upstream_of_or_within actin rod assembly PubMed 
    acts_upstream_of_or_within cellular response to ATP PubMed 
    involved_in insulin processing PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in protein folding  
    involved_in protein folding  
    involved_in response to hypoxia  
    involved_in retrograde protein transport, ER to cytosol  
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum PubMed 
    part_of endoplasmic reticulum chaperone complex PubMed 
    is_active_in endoplasmic reticulum lumen PubMed 
    located_in endoplasmic reticulum lumen  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in extracellular region  
    located_in melanosome  
    located_in midbody  
    located_in midbody  
    is_active_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    part_of protein-containing complex  
    located_in sarcoplasmic reticulum lumen  
    located_in smooth endoplasmic reticulum  
    located_in sperm plasma membrane PubMed 
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    endoplasmin
    Names
    94 kDa glucose-regulated protein
    endoplasmic reticulum resident protein 99
    heat shock protein 90 kDa beta member 1
    polymorphic tumor rejection antigen 1
    transforming growth factor alpha regulated gene 2
    tumor rejection antigen (gp96) 1
    tumor rejection antigen gp96

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011631.1NP_035761.1  endoplasmin precursor

      See identical proteins and their annotated locations for NP_035761.1

      Status: PROVISIONAL

      Source sequence(s)
      J03297
      Consensus CDS
      CCDS36019.1
      UniProtKB/Swiss-Prot
      P08113, P11427
      UniProtKB/TrEMBL
      Q3UAD6, Q91V38
      Related
      ENSMUSP00000020238.8, ENSMUST00000020238.14
      Conserved Domains (3) summary
      smart00387
      Location:96254
      HATPase_c; Histidine kinase-like ATPases
      PRK05218
      Location:74746
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:257783
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      86526705..86541308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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