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    Kcne4 potassium voltage-gated channel, Isk-related subfamily, gene 4 [ Mus musculus (house mouse) ]

    Gene ID: 57814, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcne4provided by MGI
    Official Full Name
    potassium voltage-gated channel, Isk-related subfamily, gene 4provided by MGI
    Primary source
    MGI:MGI:1891125
    See related
    Ensembl:ENSMUSG00000047330 AllianceGenome:MGI:1891125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MiRP3
    Summary
    Predicted to enable potassium channel activity; potassium channel inhibitor activity; and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in several processes, including negative regulation of delayed rectifier potassium channel activity; potassium ion export across plasma membrane; and regulation of heart rate by cardiac conduction. Predicted to be located in apical plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in heart and heart ventricle. Orthologous to human KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 7.3), limb E14.5 (RPKM 3.2) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcne4 in Genome Data Viewer
    Location:
    1 C4; 1 40.89 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78794628..78797749)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78816911..78820032)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38631 Neighboring gene STARR-seq mESC enhancer starr_01434 Neighboring gene predicted gene, 33693 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene predicted gene 29536 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01438 Neighboring gene STARR-seq mESC enhancer starr_01439 Neighboring gene predicted gene, 57565

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables potassium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in membrane repolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of heart rate by cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ventricular cardiac muscle cell action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily E member 4
    Names
    minK-related peptide 3
    minimum potassium ion channel-related peptide 3
    potassium channel subunit beta MiRP3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021342.2NP_067317.1  potassium voltage-gated channel subfamily E member 4

      See identical proteins and their annotated locations for NP_067317.1

      Status: VALIDATED

      Source sequence(s)
      AK133469, BE948375
      Consensus CDS
      CCDS15088.1
      UniProtKB/Swiss-Prot
      Q9WTW3
      Related
      ENSMUSP00000055415.7, ENSMUST00000057262.8
      Conserved Domains (1) summary
      pfam02060
      Location:1764
      ISK_Channel; Slow voltage-gated potassium channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      78794628..78797749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)