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    Fbxl4 F-box and leucine-rich repeat protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 269514, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxl4provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 4provided by MGI
    Primary source
    MGI:MGI:2140367
    See related
    Ensembl:ENSMUSG00000040410 AllianceGenome:MGI:2140367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBL4; FBL5
    Summary
    Acts upstream of or within autophagy of mitochondrion. Predicted to be located in mitochondrial intermembrane space and nuclear speck. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 7.6), genital fat pad adult (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxl4 in Genome Data Viewer
    Location:
    4 A3; 4 9.69 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (22357526..22434091)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (22357526..22434091)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09737 Neighboring gene predicted gene, 42260 Neighboring gene STARR-seq mESC enhancer starr_09738 Neighboring gene STARR-seq mESC enhancer starr_09742 Neighboring gene STARR-seq mESC enhancer starr_09743 Neighboring gene STARR-seq mESC enhancer starr_09745 Neighboring gene STARR-seq mESC enhancer starr_09746 Neighboring gene STARR-seq mESC enhancer starr_09747 Neighboring gene STARR-seq mESC enhancer starr_09748 Neighboring gene PEST proteolytic signal-containing nuclear protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_09749 Neighboring gene predicted gene, 24607 Neighboring gene STARR-seq mESC enhancer starr_09750 Neighboring gene STARR-seq mESC enhancer starr_09751 Neighboring gene predicted gene, 30731 Neighboring gene POU domain, class 3, transcription factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a. Abudureyimu M, et al. Redox Biol, 2024 Apr. PMID 38359748, Free PMC Article
    2. FBXL4 deficiency increases mitochondrial removal by autophagy. Alsina D, et al. EMBO Mol Med, 2020 Jul 7. PMID 32525278, Free PMC Article
    3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a.
      Title: FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a.
    2. FBXL4 deficiency increases mitochondrial removal by autophagy.
      Title: FBXL4 deficiency increases mitochondrial removal by autophagy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 4732456I21

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425044.1 → NP_001411973.1  F-box/LRR-repeat protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683854, AL772230
      UniProtKB/Swiss-Prot
      Q8BH70

    2. NM_001425045.1 → NP_001411974.1  F-box/LRR-repeat protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683854, AL772230
      UniProtKB/Swiss-Prot
      Q8BH70

    3. NM_001425046.1 → NP_001411975.1  F-box/LRR-repeat protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL683854, AL772230

    4. NM_172988.5 → NP_766576.1  F-box/LRR-repeat protein 4 isoform 1

      See identical proteins and their annotated locations for NP_766576.1

      Status: VALIDATED

      Source sequence(s)
      AL683854, AL772230
      Consensus CDS
      CCDS18004.1
      UniProtKB/Swiss-Prot
      Q8BH70
      UniProtKB/TrEMBL
      Q8CIC4
      Related
      ENSMUSP00000042219.4, ENSMUST00000039234.10
      Conserved Domains (3) summary
      cd09293
      Location:394 → 601
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:347 → 376
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:280 → 318
      F-box-like

    RNA

    1. NR_104378.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683854, AL772230
      Related
      ENSMUST00000185029.8

    2. NR_104379.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683854, AL772230

    3. NR_104380.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683854, AL772230
      Related
      ENSMUST00000184455.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      22357526..22434091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320233.3 → XP_017175722.1  F-box/LRR-repeat protein 4 isoform X2

      UniProtKB/TrEMBL
      Q8CIC4, V9GXH8
      Related
      ENSMUSP00000139158.2, ENSMUST00000184582.2
      Conserved Domains (3) summary
      cd09293
      Location:394 → 558
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:347 → 376
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:280 → 318
      F-box-like

    RNA

    1. XR_004941910.1 RNA Sequence

    2. XR_881066.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH70.1 GenPept UniProtKB/Swiss-Prot:Q8BH70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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