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    Dcaf1 DDB1 and CUL4 associated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 321006, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dcaf1provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 1provided by MGI
    Primary source
    MGI:MGI:2445220
    See related
    Ensembl:ENSMUSG00000040325 AllianceGenome:MGI:2445220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vprbp; mKIAA0800; B930007L02Rik
    Summary
    Predicted to enable histone H2AT120 kinase activity; nuclear estrogen receptor binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in B cell differentiation and V(D)J recombination. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of COP9 signalosome and Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in centrosome and nucleus. Orthologous to human DCAF1 (DDB1 and CUL4 associated factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.0), CNS E11.5 (RPKM 10.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dcaf1 in Genome Data Viewer
    Location:
    9 F1; 9 57.98 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106691354..106758191)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106814169..106880992)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 264 ER-phagy receptor Neighboring gene STARR-seq mESC enhancer starr_25160 Neighboring gene RAD54 like 2 (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_25163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106723938-106724121 Neighboring gene STARR-positive B cell enhancer ABC_E8313 Neighboring gene STARR-positive B cell enhancer ABC_E9334 Neighboring gene STARR-positive B cell enhancer ABC_E460 Neighboring gene RNA binding motif protein 15B Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene mesencephalic astrocyte-derived neurotrophic factor Neighboring gene predicted gene, 18542

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H2AT120 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AT120 kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear estrogen receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell competition in a multicellular organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell competition in a multicellular organism ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 1
    Names
    Vpr (HIV-1) binding protein
    protein VPRBP
    serine/threonine-protein kinase VPRBP
    NP_001015507.1
    NP_001360859.1
    NP_001360860.1
    XP_006511816.1
    XP_006511817.1
    XP_036010962.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015507.3NP_001015507.1  DDB1- and CUL4-associated factor 1 isoform 3

      See identical proteins and their annotated locations for NP_001015507.1

      Status: VALIDATED

      Source sequence(s)
      AC147636
      Consensus CDS
      CCDS23485.1
      UniProtKB/Swiss-Prot
      Q80TR8
      Related
      ENSMUSP00000123865.2, ENSMUST00000159645.8
      Conserved Domains (2) summary
      sd00039
      Location:10961132
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10921310
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001373930.1NP_001360859.1  DDB1- and CUL4-associated factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC147636
      Consensus CDS
      CCDS90657.1
      UniProtKB/Swiss-Prot
      Q3UXD5, Q6P1E2, Q80TR8, Q8CDY3
      Related
      ENSMUSP00000060025.9, ENSMUST00000055009.15
      Conserved Domains (2) summary
      sd00039
      Location:10961132
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10921310
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001373931.1NP_001360860.1  DDB1- and CUL4-associated factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC147636
      Conserved Domains (2) summary
      sd00039
      Location:10431079
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10391257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106691354..106758191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511753.4XP_006511816.1  DDB1- and CUL4-associated factor 1 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:11061142
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11021320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006511754.4XP_006511817.1  DDB1- and CUL4-associated factor 1 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:11061142
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:11021320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_036155069.1XP_036010962.1  DDB1- and CUL4-associated factor 1 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:10961132
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10921310
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_379768.5 RNA Sequence

    2. XR_004935462.1 RNA Sequence

    3. XR_004935461.1 RNA Sequence