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    Klf3 Kruppel-like transcription factor 3 (basic) [ Mus musculus (house mouse) ]

    Gene ID: 16599, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klf3provided by MGI
    Official Full Name
    Kruppel-like transcription factor 3 (basic)provided by MGI
    Primary source
    MGI:MGI:1342773
    See related
    Ensembl:ENSMUSG00000029178 AllianceGenome:MGI:1342773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bklf; Tef-2; 9930027G08Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Orthologous to human KLF3 (KLF transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 33.8), thymus adult (RPKM 20.9) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Klf3 in Genome Data Viewer
    Location:
    5 C3.1; 5 33.49 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (64960864..64990246)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (64803521..64832901)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13223 Neighboring gene predicted gene, 54285 Neighboring gene STARR-positive B cell enhancer mm9_chr5:65053140-65053441 Neighboring gene STARR-positive B cell enhancer mm9_chr5:65053800-65054101 Neighboring gene STARR-seq mESC enhancer starr_13227 Neighboring gene STARR-seq mESC enhancer starr_13228 Neighboring gene uncharacterized LOC105244755 Neighboring gene STARR-seq mESC enhancer starr_13234 Neighboring gene STARR-seq mESC enhancer starr_13235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:65155737-65155920 Neighboring gene STARR-positive B cell enhancer ABC_E10322 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:65197351-65197625 Neighboring gene predicted gene, 54286 Neighboring gene STARR-seq mESC enhancer starr_13242 Neighboring gene predicted gene, 31684 Neighboring gene STARR-seq mESC enhancer starr_13247 Neighboring gene predicted gene, 57736 Neighboring gene VISTA enhancer mm1725 Neighboring gene STARR-positive B cell enhancer ABC_E8057 Neighboring gene STARR-positive B cell enhancer ABC_E8058 Neighboring gene predicted gene, 31889

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC151315

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular response to peptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 3
    Names
    CACCC-box-binding protein BKLF
    Kruppel-like factor 3 (basic)
    basic krueppel-like factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008453.6NP_032479.1  Krueppel-like factor 3

      See identical proteins and their annotated locations for NP_032479.1

      Status: VALIDATED

      Source sequence(s)
      AC130535
      Consensus CDS
      CCDS19301.1
      UniProtKB/Swiss-Prot
      Q60980
      UniProtKB/TrEMBL
      Q545J5
      Related
      ENSMUSP00000129363.2, ENSMUST00000165536.8
      Conserved Domains (4) summary
      sd00017
      Location:261283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305330
      zf-H2C2_2; Zinc-finger double domain
      cd21577
      Location:49259
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    RNA

    1. NR_165035.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130535

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      64960864..64990246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503751.5XP_006503814.1  Krueppel-like factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006503814.1

      UniProtKB/Swiss-Prot
      Q60980
      UniProtKB/TrEMBL
      Q545J5
      Conserved Domains (4) summary
      sd00017
      Location:261283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305330
      zf-H2C2_2; Zinc-finger double domain
      cd21577
      Location:49259
      KLF3_N; N-terminal domain of Kruppel-like factor 3