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    Prickle3 prickle planar cell polarity protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 54630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prickle3provided by MGI
    Official Full Name
    prickle planar cell polarity protein 3provided by MGI
    Primary source
    MGI:MGI:1859635
    See related
    Ensembl:ENSMUSG00000031145 AllianceGenome:MGI:1859635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pk3; Lmo6; Sfc16
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in cell projection organization. Located in mitochondrion. Is expressed in several structures, including ear; early conceptus; female reproductive system; lower urinary tract; and nervous system. Used to study Leber plus disease. Orthologous to human PRICKLE3 (prickle planar cell polarity protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 15.2), stomach adult (RPKM 14.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prickle3 in Genome Data Viewer
    Location:
    X A1.1; X 3.45 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7523616..7535086)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7657379..7668197)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 1F subunit Neighboring gene synaptophysin Neighboring gene STARR-positive B cell enhancer ABC_E1215 Neighboring gene predicted gene 14703 Neighboring gene proteolipid protein 2 Neighboring gene MAGI family member, X-linked Neighboring gene peptidylprolyl isomerase A pseudogene x_14.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy. Yu J, et al. J Clin Invest, 2020 Sep 1. PMID 32516135, Free PMC Article
    2. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001
    3. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
    4. Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis. Ru J, et al. Invest Ophthalmol Vis Sci, 2020 Nov 2. PMID 33141892, Free PMC Article
    5. A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. Fu H, et al. J Neurosci, 2009 Sep 9. PMID 19741146, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
      Title: PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prickle planar cell polarity protein 3
    Names
    LIM domain only protein 6
    prickle homolog 3
    prickle-like protein 3
    triple LIM domain protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290624.2 → NP_001277553.1  prickle planar cell polarity protein 3

      See identical proteins and their annotated locations for NP_001277553.1

      Status: VALIDATED

      Source sequence(s)
      AL672231
      Consensus CDS
      CCDS72329.1
      UniProtKB/Swiss-Prot
      B1AVA9, Q80VL3, Q8CAY9
      UniProtKB/TrEMBL
      Q8CIL5
      Related
      ENSMUSP00000033485.8, ENSMUST00000033485.14
      Conserved Domains (4) summary
      cd09415
      Location:186 → 244
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:249 → 304
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:309 → 367
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:82 → 178
      PET_Prickle; The PET domain of Prickle

    RNA

    1. NR_189670.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672231

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7523616..7535086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175097.3: Suppressed sequence

      Description
      NM_175097.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VL3.1 GenPept UniProtKB/Swiss-Prot:Q80VL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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