Neurl1a neuralized E3 ubiquitin protein ligase 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neurl1aprovided by MGI
Official Full Name: neuralized E3 ubiquitin protein ligase 1Aprovided by MGI
Primary source: MGI:MGI:1334263
See related: Ensembl:ENSMUSG00000006435 AllianceGenome:MGI:1334263
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nlz; Neu1; Neur1; Neurl; Rnf67; Neurl1; 2410129E16Rik
Summary: Enables translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of filopodium assembly; positive regulation of long-term neuronal synaptic plasticity; and regulation of synapse organization. Acts upstream of or within lactation; positive regulation of epidermal growth factor-activated receptor activity; and sperm axoneme assembly. Located in several cellular components, including dendrite; perikaryon; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including limb; limb bud; nervous system; sensory organ; and skin. Orthologous to human NEURL1 (neuralized E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 25.9), cortex adult (RPKM 23.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 39.39 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47167259..47247880)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47178820..47259441)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neur1 and Neur2 are required for hippocampus-dependent spatial memory and synaptic plasticity.
Title: Neur1 and Neur2 are required for hippocampus-dependent spatial memory and synaptic plasticity.
Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1.
Title: Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1.
These results suggest a model whereby Neuralized1-dependent ubiquitination facilitates hippocampal plasticity and hippocampal-dependent memory storage by modulating the activity of CPEB3 and CPEB3-dependent protein synthesis and synapse formation.
Title: Neuralized1 activates CPEB3: a function for nonproteolytic ubiquitin in synaptic plasticity and memory storage.
molecular cloning, base sequence, amino acid sequence, and embryo tissue localization
Title: Cloning, chromosomal organization and expression analysis of Neurl, the mouse homolog of Drosophila melanogaster neuralized gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI481072 (e-PCR)
- UniSTS:166160

Neurl (e-PCR), detects polymorphism
- UniSTS:498734

AI450910 (e-PCR)
- UniSTS:186158

D19Mit38 (e-PCR), detects polymorphism
- UniSTS:128379

Neurl (e-PCR), detects polymorphism
- UniSTS:497290

NoName (e-PCR)
- UniSTS:237970

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation factor activity, non-nucleic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic spine development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of epidermal growth factor-activated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of long-term neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase NEURL1

Names: RING-type E3 ubiquitin transferase NEURL1; m-neu1; m-neuralized 1; neuralized homolog 1A; neuralized-like homolog; neuralized-like protein 1; neuralized-like protein 1A; neuralized1

NP_001156952.1

EC 2.3.2.27

NP_067335.4

EC 2.3.2.27

XP_036017349.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163480.1 → NP_001156952.1 E3 ubiquitin-protein ligase NEURL1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC132288, BC058386, BC099702

Consensus CDS

CCDS50463.1

UniProtKB/TrEMBL

Q499W5

Related

ENSMUSP00000107438.4, ENSMUST00000111807.5

Conserved Domains (4) summary

smart00588
Location:44 → 166

NEUZ; domain in neuralized proteins

pfam07177
Location:48 → 113

Neuralized; Neuralized

pfam13920
Location:501 → 550

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl02614
Location:278 → 429

SPRY; SPRY domain
NM_021360.4 → NP_067335.4 E3 ubiquitin-protein ligase NEURL1 isoform 1

See identical proteins and their annotated locations for NP_067335.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC058386, BC099702

Consensus CDS

CCDS29890.1

UniProtKB/Swiss-Prot

Q91ZT6, Q923S6, Q9CWF1, Q9QWF1

UniProtKB/TrEMBL

Q499W5

Related

ENSMUSP00000107439.4, ENSMUST00000111808.11

Conserved Domains (4) summary

smart00588
Location:61 → 183

NEUZ; domain in neuralized proteins

pfam07177
Location:65 → 130

Neuralized; Neuralized

pfam13920
Location:518 → 567

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl02614
Location:295 → 446

SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

47167259..47247880

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161456.1 → XP_036017349.1 E3 ubiquitin-protein ligase NEURL1 isoform X1

UniProtKB/TrEMBL

Q499W5

Conserved Domains (3) summary

smart00588
Location:45 → 167

NEUZ; domain in neuralized proteins

cd16785
Location:503 → 546

mRING-HC-C3HC5_NEU1A; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1A (NEURL1A) and similar proteins

pfam07177
Location:280 → 431

Neuralized