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    Utp11 UTP11 small subunit processome component [ Mus musculus (house mouse) ]

    Gene ID: 67205, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Utp11provided by MGI
    Official Full Name
    UTP11 small subunit processome componentprovided by MGI
    Primary source
    MGI:MGI:1914455
    See related
    Ensembl:ENSMUSG00000028907 AllianceGenome:MGI:1914455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cgi94; CGI-94; Utp11l; 2700082D03Rik
    Summary
    Predicted to be involved in nervous system development; positive regulation of apoptotic process; and ribosomal small subunit biogenesis. Predicted to be located in cytoplasm and extracellular space. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in cerebral cortex ventricular layer; trigeminal ganglion; and vertebral axis musculature. Orthologous to human UTP11 (UTP11 small subunit processome component). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 16.5), placenta adult (RPKM 13.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Utp11 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.87 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124571173..124587395, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124678232..124693610, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene POU domain, class 3, transcription factor 1 Neighboring gene predicted gene, 38545 Neighboring gene STARR-positive B cell enhancer ABC_E6213 Neighboring gene four and a half LIM domains 3 Neighboring gene STARR-seq mESC enhancer starr_11340 Neighboring gene STARR-positive B cell enhancer ABC_E6214 Neighboring gene splicing factor 3a, subunit 3 Neighboring gene PRELI domain containing 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    probable U3 small nucleolar RNA-associated protein 11
    Names
    U3 snoRNA-associated protein 11
    UTP11-like protein
    UTP11-like, U3 small nucleolar ribonucleoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419148.1 → NP_001406077.1  probable U3 small nucleolar RNA-associated protein 11 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL606907

    2. NM_001419149.1 → NP_001406078.1  probable U3 small nucleolar RNA-associated protein 11 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL606907

    3. NM_026031.4 → NP_080307.1  probable U3 small nucleolar RNA-associated protein 11 isoform a

      See identical proteins and their annotated locations for NP_080307.1

      Status: VALIDATED

      Source sequence(s)
      AL606907
      Consensus CDS
      CCDS18623.1
      UniProtKB/Swiss-Prot
      Q3UI21, Q9CVB5, Q9CZJ1
      Related
      ENSMUSP00000030738.8, ENSMUST00000030738.8
      Conserved Domains (1) summary
      pfam03998
      Location:13 → 253
      Utp11; Utp11 protein

    RNA

    1. NR_185021.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606907

    2. NR_185022.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606907

    3. NR_185023.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606907

    4. NR_185024.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606907

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124571173..124587395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164362.1 → XP_036020255.1  probable U3 small nucleolar RNA-associated protein 11 isoform X2

      Conserved Domains (1) summary
      pfam03998
      Location:5 → 144
      Utp11; Utp11 protein

    2. XM_011240592.4 → XP_011238894.1  probable U3 small nucleolar RNA-associated protein 11 isoform X1

      UniProtKB/TrEMBL
      Q9D948
      Conserved Domains (1) summary
      pfam03998
      Location:1 → 184
      Utp11; Utp11 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZJ1.1 GenPept UniProtKB/Swiss-Prot:Q9CZJ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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