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    Tedc1 tubulin epsilon and delta complex 1 [ Mus musculus (house mouse) ]

    Gene ID: 104732, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tedc1provided by MGI
    Official Full Name
    tubulin epsilon and delta complex 1provided by MGI
    Primary source
    MGI:MGI:2144738
    See related
    Ensembl:ENSMUSG00000037466 AllianceGenome:MGI:2144738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFLJ00116; 4930427A07Rik
    Summary
    Involved in positive regulation of smoothened signaling pathway. Located in centriole and cilium. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human TEDC1 (tubulin epsilon and delta complex 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 12.7), testis adult (RPKM 11.0) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tedc1 in Genome Data Viewer
    Location:
    12 F1; 12 61.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113118639..113135102)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113156421..113165458)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30599 Neighboring gene cysteine-rich protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114406329-114406556 Neighboring gene origin of replication downstream of immunoglobulin heavy chain (Igh) locus Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114425816-114425969 Neighboring gene transmembrane protein 121 Neighboring gene STARR-seq mESC enhancer starr_33382 Neighboring gene predicted gene, 25622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00116

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin epsilon and delta complex protein 1
    Names
    uncharacterized protein C14orf80 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134041.3 → NP_598802.2  tubulin epsilon and delta complex protein 1

      See identical proteins and their annotated locations for NP_598802.2

      Status: VALIDATED

      Source sequence(s)
      AK167092, BB615126, BI134858
      Consensus CDS
      CCDS49196.1
      UniProtKB/Swiss-Prot
      E9Q930, Q3TK97, Q3UK37
      Related
      ENSMUSP00000035351.9, ENSMUST00000049271.13
      Conserved Domains (3) summary
      COG0841
      Location:285 → 382
      AcrB; Multidrug efflux pump subunit AcrB [Defense mechanisms]
      pfam14970
      Location:41 → 221
      DUF4509; Domain of unknown function (DUF4509)
      pfam14971
      Location:266 → 418
      DUF4510; Domain of unknown function (DUF4510)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      113118639..113135102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157146.1 → XP_036013039.1  tubulin epsilon and delta complex protein 1 isoform X1

      UniProtKB/TrEMBL
      Q8R232
      Conserved Domains (2) summary
      pfam14970
      Location:1 → 56
      DUF4509; Domain of unknown function (DUF4509)
      pfam14971
      Location:101 → 253
      DUF4510; Domain of unknown function (DUF4510)

    2. XM_036157147.1 → XP_036013040.1  tubulin epsilon and delta complex protein 1 isoform X1

      UniProtKB/TrEMBL
      Q8R232
      Conserved Domains (2) summary
      pfam14970
      Location:1 → 56
      DUF4509; Domain of unknown function (DUF4509)
      pfam14971
      Location:101 → 253
      DUF4510; Domain of unknown function (DUF4510)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UK37.2 GenPept UniProtKB/Swiss-Prot:Q3UK37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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