U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pa2g4 proliferation-associated 2G4 [ Mus musculus (house mouse) ]

    Gene ID: 18813, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pa2g4provided by MGI
    Official Full Name
    proliferation-associated 2G4provided by MGI
    Primary source
    MGI:MGI:894684
    See related
    Ensembl:ENSMUSG00000025364 AllianceGenome:MGI:894684
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ebp1; 38kDa; Plfap
    Summary
    Predicted to enable nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of cell differentiation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; jaw; limb; and lung mesenchyme. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 85.0), CNS E11.5 (RPKM 68.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pa2g4 in Genome Data Viewer
    Location:
    10 D3; 10 77.09 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128393635..128401803, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128557766..128565934, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2973 Neighboring gene ribosomal protein L41 Neighboring gene predicted gene 9176 Neighboring gene erb-b2 receptor tyrosine kinase 3 Neighboring gene microRNA 6917 Neighboring gene STARR-seq mESC enhancer starr_28288 Neighboring gene STARR-positive B cell enhancer ABC_E10660 Neighboring gene predicted gene 9182

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    proliferation-associated protein 2G4
    Names
    ErbB3-binding protein 1
    IRES-specific cellular trans-acting factor 45 kDa
    ITAF45
    mpp1
    proliferation-associated 2G4, 38kD
    proliferation-associated protein 1
    protein p38-2G4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011119.3NP_035249.1  proliferation-associated protein 2G4

      See identical proteins and their annotated locations for NP_035249.1

      Status: PROVISIONAL

      Source sequence(s)
      AK168582
      Consensus CDS
      CCDS24282.1
      UniProtKB/Swiss-Prot
      P50580
      UniProtKB/TrEMBL
      D3YVH7, Q3TGU7, Q3UMW2
      Related
      ENSMUSP00000026425.7, ENSMUST00000026425.13
      Conserved Domains (1) summary
      TIGR00495
      Location:1388
      crvDNA_42K; 42K curved DNA binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128393635..128401803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)