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    Retn resistin [ Mus musculus (house mouse) ]

    Gene ID: 57264, updated on 27-Nov-2024

    Summary

    Official Symbol
    Retnprovided by MGI
    Official Full Name
    resistinprovided by MGI
    Primary source
    MGI:MGI:1888506
    See related
    Ensembl:ENSMUSG00000012705 AllianceGenome:MGI:1888506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADSF; Rstn; Xcp4; Fizz3
    Summary
    Predicted to enable hormone activity. Predicted to be involved in several processes, including negative regulation of feeding behavior; positive regulation of cell communication; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Is expressed in adipose tissue. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 408.3), mammary gland adult (RPKM 151.5) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Retn in Genome Data Viewer
    Location:
    8 A1.1; 8 1.92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3705770..3709818)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3655770..3659818)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene PET100 homolog Neighboring gene Purkinje cell protein 2 (L7) Neighboring gene syntaxin binding protein 2 Neighboring gene mast cell expressed membrane protein 1 Neighboring gene Foxo1 corepressor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    resistin
    Names
    adipose tissue-specific secretory factor
    adipose-specific cysteine-rich secreted protein A12-alpha
    cysteine-rich secreted protein FIZZ3
    dominant inhibitory adipocyte-specific secretory factor
    found in inflammatory zone 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204959.1NP_001191888.1  resistin precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK131613, BC051196
      Consensus CDS
      CCDS22068.1
      UniProtKB/Swiss-Prot
      Q99P87
      UniProtKB/TrEMBL
      Q3V2F6, Q5BMX4
      Related
      ENSMUSP00000012849.9, ENSMUST00000012849.15
      Conserved Domains (1) summary
      pfam06954
      Location:26110
      Resistin
    2. NM_022984.4NP_075360.1  resistin precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF510100
      Consensus CDS
      CCDS22068.1
      UniProtKB/Swiss-Prot
      Q99P87
      UniProtKB/TrEMBL
      Q3V2F6, Q5BMX4
      Related
      ENSMUSP00000133024.3, ENSMUST00000169234.3
      Conserved Domains (1) summary
      pfam06954
      Location:26110
      Resistin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      3705770..3709818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)