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    Frmpd3 FERM and PDZ domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 245643, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Frmpd3provided by MGI
    Official Full Name
    FERM and PDZ domain containing 3provided by MGI
    Primary source
    MGI:MGI:3646547
    See related
    Ensembl:ENSMUSG00000042425 AllianceGenome:MGI:3646547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm29750; EG245643; B930041G04
    Summary
    Orthologous to human FRMPD3 (FERM and PDZ domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 3.7), frontal lobe adult (RPKM 3.6) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Frmpd3 in Genome Data Viewer
    Location:
    X F1; X
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (139177867..139336216)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140277123..140435467)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39537 Neighboring gene predicted gene, 57672 Neighboring gene STARR-seq mESC enhancer starr_48002 Neighboring gene STARR-seq mESC enhancer starr_48003 Neighboring gene predicted gene, 32113 Neighboring gene microRNA 3475 Neighboring gene STARR-seq mESC enhancer starr_48004 Neighboring gene STARR-seq mESC enhancer starr_48005 Neighboring gene STARR-positive B cell enhancer mm9_chrX:136990945-136991245 Neighboring gene STARR-seq mESC enhancer starr_48006 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene STARR-positive B cell enhancer mm9_chrX:137038534-137038835 Neighboring gene predicted gene, 39538

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    FERM and PDZ domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320946.1 → NP_001307875.1  FERM and PDZ domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672297
      Consensus CDS
      CCDS85809.1
      UniProtKB/TrEMBL
      A0A140LIW3, A0A3G0YW97
      Related
      ENSMUSP00000146983.2, ENSMUST00000208130.2
      Conserved Domains (5) summary
      smart00295
      Location:148 → 367
      B41; Band 4.1 homologues
      PHA03307
      Location:847 → 1224
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:19 → 95
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:363 → 466
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17169
      Location:145 → 237
      FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

    2. NM_001388454.1 → NP_001375383.1  FERM and PDZ domain-containing protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672297, AL714021
      UniProtKB/TrEMBL
      A0A140LIW3, A0A3G0YW97
      Conserved Domains (5) summary
      smart00295
      Location:148 → 367
      B41; Band 4.1 homologues
      PHA03307
      Location:847 → 1224
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:19 → 95
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13183
      Location:363 → 466
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17169
      Location:145 → 237
      FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

    3. NM_001388455.1 → NP_001375384.1  FERM and PDZ domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672297, AL714021
      UniProtKB/TrEMBL
      A0A3G0YW97
      Conserved Domains (4) summary
      smart00295
      Location:13 → 232
      B41; Band 4.1 homologues
      PHA03307
      Location:712 → 1089
      PHA03307; transcriptional regulator ICP4; Provisional
      cd13183
      Location:228 → 331
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17169
      Location:10 → 102
      FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

    4. NM_001388456.1 → NP_001375385.1  FERM and PDZ domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672297, AL714021
      UniProtKB/TrEMBL
      A0A3G0YW97
      Conserved Domains (4) summary
      smart00295
      Location:13 → 232
      B41; Band 4.1 homologues
      PHA03307
      Location:712 → 1089
      PHA03307; transcriptional regulator ICP4; Provisional
      cd13183
      Location:228 → 331
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17169
      Location:10 → 102
      FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

    5. NM_001388457.1 → NP_001375386.1  FERM and PDZ domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672297, AL714021
      UniProtKB/TrEMBL
      A0A3G0YW97
      Conserved Domains (4) summary
      smart00295
      Location:13 → 232
      B41; Band 4.1 homologues
      PHA03307
      Location:712 → 1089
      PHA03307; transcriptional regulator ICP4; Provisional
      cd13183
      Location:228 → 331
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17169
      Location:10 → 102
      FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

    6. NM_001388458.1 → NP_001375387.1  FERM and PDZ domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672297
      UniProtKB/TrEMBL
      A0A3G0YW97
      Conserved Domains (4) summary
      smart00295
      Location:13 → 232
      B41; Band 4.1 homologues
      PHA03307
      Location:712 → 1089
      PHA03307; transcriptional regulator ICP4; Provisional
      cd13183
      Location:228 → 331
      FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
      cd17169
      Location:10 → 102
      FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      139177867..139336216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528657.3 → XP_006528720.1  FERM and PDZ domain-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006528720.1

      Conserved Domains (3) summary
      PTZ00449
      Location:571 → 889
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:365 → 742
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15449
      Location:590 → 738
      Retinal; Retinal protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177750.6: Suppressed sequence

      Description
      NM_177750.6: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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