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    Zc3h12c zinc finger CCCH type containing 12C [ Mus musculus (house mouse) ]

    Gene ID: 244871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zc3h12cprovided by MGI
    Official Full Name
    zinc finger CCCH type containing 12Cprovided by MGI
    Primary source
    MGI:MGI:3026959
    See related
    Ensembl:ENSMUSG00000035164 AllianceGenome:MGI:3026959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1726; A230108E06; C230027N18Rik
    Summary
    Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12C (zinc finger CCCH-type containing 12C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.2), whole brain E14.5 (RPKM 3.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h12c in Genome Data Viewer
    Location:
    9 A5.3; 9 28.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (52020869..52080028, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (52109569..52168730, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene radixin Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene microRNA 6244 Neighboring gene STARR-positive B cell enhancer ABC_E3829 Neighboring gene predicted gene, 25562 Neighboring gene STARR-positive B cell enhancer mm9_chr9:52157388-52157688 Neighboring gene STARR-seq mESC enhancer starr_24135 Neighboring gene basic transcription factor 3, pseudogene 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases. Garg A, et al. Nucleic Acids Res, 2021 May 21. PMID 33950203, Free PMC Article
    2. Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology. Wawro M, et al. Int J Mol Sci, 2021 Jul 7. PMID 34298932, Free PMC Article
    3. Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages. Guo G, et al. Mol Immunol, 2020 Dec. PMID 33157351
    4. The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response. Liu B, et al. Nat Commun, 2021 Jul 2. PMID 34215755, Free PMC Article
    5. Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. von Gamm M, et al. J Exp Med, 2019 Jul 1. PMID 31126966, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology.
      Title: Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology.
    2. The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
      Title: The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
    3. PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
      Title: PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
    4. Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages.
      Title: Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages.
    5. required for immune homeostasis and regulation of the interferon pathway
      Title: Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
    6. MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
      Title: A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1726

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ribonuclease ZC3H12C
    Names
    regnase-3
    zinc finger CCCH domain-containing protein 12C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162921.2 → NP_001156393.1  probable ribonuclease ZC3H12C isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009732
      Consensus CDS
      CCDS52794.1
      UniProtKB/TrEMBL
      E9Q1I3
      Related
      ENSMUSP00000127603.2, ENSMUST00000165519.2
      Conserved Domains (2) summary
      PHA03160
      Location:519 → 762
      PHA03160; hypothetical protein; Provisional
      pfam11977
      Location:264 → 420
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    2. NM_001368810.1 → NP_001355739.1  probable ribonuclease ZC3H12C isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009732
      Conserved Domains (2) summary
      cl25932
      Location:500 → 743
      Peptidase_S21; Assemblin (Peptidase family S21)
      cd18729
      Location:249 → 379
      PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      52020869..52080028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510333.4 → XP_006510396.1  probable ribonuclease ZC3H12C isoform X1

      See identical proteins and their annotated locations for XP_006510396.1

      UniProtKB/Swiss-Prot
      Q5DTV4
      Related
      ENSMUSP00000150821.2, ENSMUST00000213645.2
      Conserved Domains (5) summary
      cl25932
      Location:500 → 743
      Peptidase_S21; Assemblin (Peptidase family S21)
      cd18729
      Location:249 → 379
      PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
      pfam18039
      Location:163 → 204
      UBA_6; UBA-like domain
      pfam18044
      Location:416 → 434
      zf-CCCH_4; CCCH-type zinc finger
      pfam18561
      Location:836 → 879
      Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTV4.2 GenPept UniProtKB/Swiss-Prot:Q5DTV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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