Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts18provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 18provided by MGI
Primary source: MGI:MGI:2442600
See related: Ensembl:ENSMUSG00000053399 AllianceGenome:MGI:2442600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADAMTS21; 9630038L21; E130314N14Rik
Summary: Predicted to enable metalloendopeptidase activity. Acts upstream of or within negative regulation of platelet aggregation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including alimentary system; brain; eye; lung; and male reproductive gland or organ. Orthologous to human ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E14 (RPKM 1.9), CNS E18 (RPKM 1.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 59.65 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (114423755..114575975, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (113697123..113849343, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.
Title: ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.
ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice.
Title: ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice.
Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.
Title: Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.
ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice.
Title: ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice.
ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice.
Title: ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice.
Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.
Title: Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.
Adamts18 links luminal hormone receptor signaling to basement membrane remodeling and stem cell activation.
Title: The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche.
The underlying molecular mechanisms could be attributed in part to the abnormal vascular remodeling, including deficiency of carotid body (glomus) and aberrant carotid basal lamina. These results indicate a novel function of ADAMTS18 in vascular remodeling and associated thrombus formation.
Title: Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice.
Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/beta-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in a mouse model.
Title: Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer.
these data demonstrate a thrombin cleavage site and confirm a short form of ADAMTS-18 presents in vivo.
Title: Identification of a thrombin cleavage site and a short form of ADAMTS-18.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adamts18 (e-PCR), detects polymorphism
- UniSTS:532646

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in eye development	IEA Inferred from Electronic Annotation more info
involved_in eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 18

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403922.1 → NP_001390851.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform b precursor

Status: VALIDATED

Source sequence(s)

AC108856, AC125463
NM_001403923.1 → NP_001390852.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform c

Status: VALIDATED

Source sequence(s)

AC108856, AC125463
NM_001403924.1 → NP_001390853.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform c

Status: VALIDATED

Source sequence(s)

AC108856, AC125463
NM_172466.4 → NP_766054.2 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform a precursor

See identical proteins and their annotated locations for NP_766054.2

Status: VALIDATED

Source sequence(s)

AC108856, AC125463

Consensus CDS

CCDS40485.1

UniProtKB/Swiss-Prot

E9QNK0, Q4VC17, Q8BZD1

UniProtKB/TrEMBL

B7ZMV1

Related

ENSMUSP00000090801.5, ENSMUST00000093113.5

Conserved Domains (7) summary

smart00209
Location:592 → 644

TSP1; Thrombospondin type 1 repeats

cd04273
Location:293 → 494

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:749 → 861

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:65 → 203

Pep_M12B_propep; Reprolysin family propeptide

pfam08686
Location:1186 → 1216

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:511 → 578

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:935 → 991

TSP1_ADAMTS; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

114423755..114575975 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530797.2 → XP_006530860.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X3

See identical proteins and their annotated locations for XP_006530860.1

UniProtKB/TrEMBL

B7ZMV1

Conserved Domains (6) summary

smart00209
Location:512 → 564

TSP1; Thrombospondin type 1 repeats

cd04273
Location:213 → 414

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:80 → 123

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:669 → 781

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1106 → 1136

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:431 → 498

ADAM_CR_2; ADAM cysteine-rich domain
XM_006530795.4 → XP_006530858.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1

UniProtKB/TrEMBL

B7ZMV1

Conserved Domains (6) summary

smart00209
Location:626 → 678

TSP1; Thrombospondin type 1 repeats

cd04273
Location:327 → 528

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:99 → 237

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:783 → 895

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1220 → 1250

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:545 → 612

ADAM_CR_2; ADAM cysteine-rich domain
XM_030243369.1 → XP_030099229.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X5

Conserved Domains (5) summary

smart00209
Location:180 → 232

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:337 → 449

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:774 → 804

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:99 → 166

ADAM_CR_2; ADAM cysteine-rich domain

cl00064
Location:1 → 82

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_030243370.1 → XP_030099230.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X5

Conserved Domains (5) summary

smart00209
Location:180 → 232

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:337 → 449

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:774 → 804

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:99 → 166

ADAM_CR_2; ADAM cysteine-rich domain

cl00064
Location:1 → 82

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_017312629.2 → XP_017168118.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X2

UniProtKB/TrEMBL

B7ZMV1

Conserved Domains (6) summary

smart00209
Location:548 → 600

TSP1; Thrombospondin type 1 repeats

cd04273
Location:249 → 450

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:116 → 159

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:705 → 817

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1142 → 1172

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:467 → 534

ADAM_CR_2; ADAM cysteine-rich domain
XM_006530801.4 → XP_006530864.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X4

See identical proteins and their annotated locations for XP_006530864.1

UniProtKB/TrEMBL

Q8BKA1

Conserved Domains (5) summary

smart00209
Location:420 → 472

TSP1; Thrombospondin type 1 repeats

cd04273
Location:121 → 322

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:577 → 689

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1014 → 1044

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:339 → 406

ADAM_CR_2; ADAM cysteine-rich domain
XM_017312631.2 → XP_017168120.1 A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X6

Conserved Domains (4) summary

smart00209
Location:626 → 678

TSP1; Thrombospondin type 1 repeats

cd04273
Location:327 → 528

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:99 → 237

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:545 → 612

ADAM_CR_2; ADAM cysteine-rich domain