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    Zfp2 zinc finger protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 22678, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zfp2provided by MGI
    Official Full Name
    zinc finger protein 2provided by MGI
    Primary source
    MGI:MGI:99167
    See related
    Ensembl:ENSMUSG00000049321 AllianceGenome:MGI:99167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKR2; Fnp-2; Zfp-2; mkr-2; mszf87; 9930007F06Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including nervous system; urinary system; and vertebral pre-cartilage condensation. Orthologous to human ZFP2 (ZFP2 zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.3), whole brain E14.5 (RPKM 2.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp2 in Genome Data Viewer
    Location:
    11 B1.3; 11 30.94 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50788092..50807043, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50897265..50916216, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6979 Neighboring gene glutamate receptor, metabotropic 6 Neighboring gene zinc finger protein 454 Neighboring gene STARR-seq mESC enhancer starr_29409 Neighboring gene zinc finger protein 354B Neighboring gene RIKEN cDNA 4933414I15 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons. Chowdhury K, et al. EMBO J, 1988 May. PMID 3409867, Free PMC Article
    2. A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Chowdhury K, et al. Cell, 1987 Mar 13. PMID 3815523
    3. Zinc finger protein gene complexes on mouse chromosomes 8 and 11. Nadeau JH, et al. Genomics, 1990 Nov. PMID 1981050
    4. ILDR2 stabilization is regulated by its interaction with GRP78. Watanabe K, et al. Sci Rep, 2021 Apr 16. PMID 33863978, Free PMC Article
    5. Zinc finger protein genes in the mouse genome. Ashworth A, et al. Mamm Genome, 1991. PMID 1797234

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107189

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein ZFP2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044697.2 → NP_001038162.1  zinc finger protein ZFP2

      See identical proteins and their annotated locations for NP_001038162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
      Source sequence(s)
      AK141471, BC052029, BY107004
      Consensus CDS
      CCDS36148.1
      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Related
      ENSMUSP00000112079.2, ENSMUST00000116378.8
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001044698.2 → NP_001038163.1  zinc finger protein ZFP2

      See identical proteins and their annotated locations for NP_001038163.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
      Source sequence(s)
      AK141471, BC052029, BY107004
      Consensus CDS
      CCDS36148.1
      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001044700.2 → NP_001038165.1  zinc finger protein ZFP2

      See identical proteins and their annotated locations for NP_001038165.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
      Source sequence(s)
      BC052029, BC089506, BY107004
      Consensus CDS
      CCDS36148.1
      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001294323.1 → NP_001281252.1  zinc finger protein ZFP2

      See identical proteins and their annotated locations for NP_001281252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
      Source sequence(s)
      AL627215, BC052029, BY107004, CJ044064
      Consensus CDS
      CCDS36148.1
      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Related
      ENSMUSP00000104757.2, ENSMUST00000109129.8
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_178447.3 → NP_848542.1  zinc finger protein ZFP2

      See identical proteins and their annotated locations for NP_848542.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 2, 3, 4, 6 and 7 encode the same protein.
      Source sequence(s)
      AL627215, BC052029, BY107004
      Consensus CDS
      CCDS36148.1
      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Related
      ENSMUSP00000104756.2, ENSMUST00000109128.8
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50788092..50807043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314506.2 → XP_017169995.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030245935.2 → XP_030101795.1  zinc finger protein ZFP2 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:131 → 484
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:417 → 437
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030245940.1 → XP_030101800.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036156640.1 → XP_036012533.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036156638.1 → XP_036012531.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036156639.1 → XP_036012532.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_030245936.1 → XP_030101796.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_036156637.1 → XP_036012530.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_030245938.1 → XP_030101798.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. XM_030245941.1 → XP_030101801.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. XM_030245937.2 → XP_030101797.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. XM_030245939.2 → XP_030101799.1  zinc finger protein ZFP2 isoform X2

      UniProtKB/Swiss-Prot
      P08043, Q3V280, Q8R012
      Conserved Domains (2) summary
      COG5048
      Location:96 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001044699.1: Suppressed sequence

      Description
      NM_001044699.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    2. NM_009550.1: Suppressed sequence

      Description
      NM_009550.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08043.2 GenPept UniProtKB/Swiss-Prot:P08043

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