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    Cntnap5b contactin associated protein-like 5B [ Mus musculus (house mouse) ]

    Gene ID: 241175, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cntnap5bprovided by MGI
    Official Full Name
    contactin associated protein-like 5Bprovided by MGI
    Primary source
    MGI:MGI:3664583
    See related
    Ensembl:ENSMUSG00000067028 AllianceGenome:MGI:3664583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Caspr5-2; C230078M14Rik
    Summary
    Predicted to be involved in cell adhesion. Predicted to be located in cell junction; membrane; and neuron projection. Is expressed in brain and spinal cord. Orthologous to human CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 3.6), CNS E18 (RPKM 1.8) and 5 other tissues See more
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    Genomic context

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    See Cntnap5b in Genome Data Viewer
    Location:
    1 E1.1; 1 48.19 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (99700006..100418324)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (99772246..100490599)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23434 Neighboring gene STARR-seq mESC enhancer starr_01796 Neighboring gene STARR-seq mESC enhancer starr_01797 Neighboring gene predicted gene, 18248 Neighboring gene predicted gene, 51641 Neighboring gene peroxiredoxin 2, pseudogene 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:102076636-102076937 Neighboring gene predicted gene, 53575 Neighboring gene predicted gene, 41923 Neighboring gene predicted gene, 23602 Neighboring gene predicted gene 29667 Neighboring gene baculoviral IAP repeat-containing 2 pseudogene Neighboring gene survival motor neuron 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Weichenhan D, et al. Mamm Genome, 2008 Oct-Dec. PMID 18949514
    2. New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene. Traut W, et al. Mamm Genome, 2006 Jul. PMID 16845472
    3. Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Platt RJ, et al. Cell Rep, 2017 Apr 11. PMID 28402856, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    contactin-associated protein like 5-2
    Names
    cell recognition molecule Caspr5-2
    cell recognition molecule Caspr5b
    contactin-associated protein-like 5b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172851.3 → NP_766439.2  contactin-associated protein like 5-2 precursor

      See identical proteins and their annotated locations for NP_766439.2

      Status: VALIDATED

      Source sequence(s)
      AC102217, AC135080, AC157363, AC158402, AC161355, AC163496
      Consensus CDS
      CCDS35682.1
      UniProtKB/Swiss-Prot
      Q0V8T8, Q2PAX9, Q8BUT8
      Related
      ENSMUSP00000083944.4, ENSMUST00000086738.10
      Conserved Domains (6) summary
      smart00231
      Location:56 → 174
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00057
      Location:56 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:779 → 923
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:550 → 581
      EGF; EGF-like domain
      pfam02210
      Location:395 → 521
      Laminin_G_2; Laminin G domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      99700006..100418324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529594.5 → XP_006529657.1  contactin-associated protein like 5-2 isoform X1

      Conserved Domains (5) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00057
      Location:56 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:780 → 924
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:551 → 582
      EGF; EGF-like domain
      pfam02210
      Location:396 → 519
      Laminin_G_2; Laminin G domain

    2. XM_036165066.1 → XP_036020959.1  contactin-associated protein like 5-2 isoform X3

      Conserved Domains (3) summary
      cd00110
      Location:150 → 294
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:318 → 351
      EGF; EGF-like domain
      pfam02210
      Location:402 → 530
      Laminin_G_2; Laminin G domain

    3. XM_036165065.1 → XP_036020958.1  contactin-associated protein like 5-2 isoform X2

      UniProtKB/TrEMBL
      B7ZP40
      Conserved Domains (3) summary
      cd00110
      Location:198 → 342
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:366 → 399
      EGF; EGF-like domain
      pfam02210
      Location:450 → 578
      Laminin_G_2; Laminin G domain

    4. XM_011248005.2 → XP_011246307.1  contactin-associated protein like 5-2 isoform X3

      Conserved Domains (3) summary
      cd00110
      Location:150 → 294
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:318 → 351
      EGF; EGF-like domain
      pfam02210
      Location:402 → 530
      Laminin_G_2; Laminin G domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0V8T8.1 GenPept UniProtKB/Swiss-Prot:Q0V8T8

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