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    Zfp597 zinc finger protein 597 [ Mus musculus (house mouse) ]

    Gene ID: 71063, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp597provided by MGI
    Official Full Name
    zinc finger protein 597provided by MGI
    Primary source
    MGI:MGI:1918313
    See related
    Ensembl:ENSMUSG00000039789 AllianceGenome:MGI:1918313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933407K12Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF597 (zinc finger protein 597). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 3.2), CNS E18 (RPKM 3.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp597 in Genome Data Viewer
    Location:
    16 A1; 16 2.27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3679408..3702241, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (3861544..3884377, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39909 Neighboring gene predicted gene, 41409 Neighboring gene STARR-seq mESC enhancer starr_39910 Neighboring gene STARR-positive B cell enhancer ABC_E5522 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene zinc finger protein 174 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872304-3872526 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872697-3872880 Neighboring gene STARR-positive B cell enhancer mm9_chr16:3884448-3884748 Neighboring gene N(alpha)-acetyltransferase 60, NatF catalytic subunit Neighboring gene RIKEN cDNA 1700037C18 gene Neighboring gene predicted gene, 41410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3908535-3908837 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3909019-3909128 Neighboring gene clusterin associated protein 1 Neighboring gene prothymosin alpha-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain. Tanabe Y, et al. J Neurochem, 2010 Feb. PMID 19968752
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results reveal novel biological and pathological roles of HIT-4 in brain development and/or maintenance in mice.
      Title: Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118564

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 597

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033159.2 → NP_001028331.2  zinc finger protein 597

      Status: VALIDATED

      Source sequence(s)
      AAHY01125318, AK016727
      Consensus CDS
      CCDS27911.1
      UniProtKB/TrEMBL
      E9Q6S0
      Related
      ENSMUSP00000088009.5, ENSMUST00000090522.5
      Conserved Domains (5) summary
      COG5048
      Location:183 → 242
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:157 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:183 → 205
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:16 → 53
      KRAB; KRAB box
      pfam13465
      Location:197 → 222
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      3679408..3702241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522576.5 → XP_006522639.1  zinc finger protein 597 isoform X1

      Conserved Domains (3) summary
      COG5189
      Location:77 → 160
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:54 → 74
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:94 → 119
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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