Tmod2 tropomodulin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmod2provided by RGD
Official Full Name: tropomodulin 2provided by RGD
Primary source: RGD:61948
See related: EnsemblRapid:ENSRNOG00000010447 AllianceGenome:RGD:61948
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables actin binding activity and tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within learning or memory; neuron-neuron synaptic transmission; and positive regulation of G protein-coupled receptor signaling pathway. Located in growth cone. Orthologous to human TMOD2 (tropomodulin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 177.9), Heart (RPKM 43.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (85197222..85250627, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (76316736..76366003, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (82505947..82547450, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In hippocampal neurons, TMOD2 regulates dendritic arborization.
Title: Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation.
Tmod1 increases dendritic branching distal from the cell body and the number of filopodia/thin spines. Tmod2 increases dendritic branching proximal to the cell body and the number of mature dendritic spines.
Title: Tropomodulin isoforms utilize specific binding functions to modulate dendrite development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW535177 (e-PCR)
- UniSTS:247195

RH138018 (e-PCR)
- UniSTS:220105

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	IDA Inferred from Direct Assay more info	PubMed
enables tropomyosin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	TAS Traceable Author Statement more info	PubMed
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron-neuron synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron-neuron synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in pointed-end actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
is_active_in striated muscle thin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tropomodulin-2

Names: N-Tmod; neuronal tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031613.2 → NP_113801.1 tropomodulin-2

See identical proteins and their annotated locations for NP_113801.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P70566

UniProtKB/TrEMBL

A0A8I5ZMG0, A6I1E0

Related

ENSRNOP00000014124.3, ENSRNOT00000014124.5

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:197 → 291

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

85197222..85250627 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243407.5 → XP_006243469.1 tropomodulin-2 isoform X1

See identical proteins and their annotated locations for XP_006243469.1

UniProtKB/Swiss-Prot

P70566

UniProtKB/TrEMBL

A0A8I5ZMG0, A6I1E0

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:197 → 291

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_008766331.4 → XP_008764553.1 tropomodulin-2 isoform X1

See identical proteins and their annotated locations for XP_008764553.1

UniProtKB/Swiss-Prot

P70566

UniProtKB/TrEMBL

A0A8I5ZMG0, A6I1E0

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:197 → 291

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006243408.5 → XP_006243470.1 tropomodulin-2 isoform X1

See identical proteins and their annotated locations for XP_006243470.1

UniProtKB/Swiss-Prot

P70566

UniProtKB/TrEMBL

A0A8I5ZMG0, A6I1E0

Conserved Domains (2) summary

pfam03250
Location:5 → 146

Tropomodulin

cl39015
Location:197 → 291

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...