Pramel7 PRAME like 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pramel7provided by MGI
Official Full Name: PRAME like 7provided by MGI
Primary source: MGI:MGI:2156391
See related: Ensembl:ENSMUSG00000025839 AllianceGenome:MGI:2156391
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in blastocyst formation and stem cell population maintenance. Acts upstream of or within regulation of ERK1 and ERK2 cascade and somatic stem cell population maintenance. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in 2-cell stage embryo; 4-cell stage embryo; compacted morula; and inner cell mass. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 2 D; 2 49.86 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (87319432..87322762, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (87489088..87492418, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pramel7 (PRAME-like 7), a protein highly expressed in the inner cell mass but expressed at low levels in embryonic stem cells, targets proteasomal degradation of UHRF1, a key factor for DNA methylation maintenance.
Title: Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.
Pramel7 represents a central and essential factor in the signaling network regulating pluripotency and self-renewal in embryonic stem cells.
Title: Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pramel7 (e-PCR), detects polymorphism
- UniSTS:254305

RH127022 (e-PCR)
- UniSTS:209776

RH125608 (e-PCR)
- UniSTS:162422

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: preferentially expressed antigen in melanoma-like protein 7

Names: preferentially expressed antigen in melanoma like 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178250.2 → NP_839981.1 preferentially expressed antigen in melanoma-like protein 7

See identical proteins and their annotated locations for NP_839981.1

Status: PROVISIONAL

Source sequence(s)

AF490343

Consensus CDS

CCDS16293.1

UniProtKB/Swiss-Prot

Q7TPY5, Q810Y8

Related

ENSMUSP00000026957.4, ENSMUST00000026957.4

Conserved Domains (1) summary

sd00034
Location:269 → 292

LRR_AMN1; leucine-rich repeat [structural motif]