Rtn4rl2 reticulon 4 receptor-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rtn4rl2provided by MGI
Official Full Name: reticulon 4 receptor-like 2provided by MGI
Primary source: MGI:MGI:2669796
See related: Ensembl:ENSMUSG00000050896 AllianceGenome:MGI:2669796
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ngr2; Ngrh1; Ngrl3
Summary: Predicted to enable signaling receptor activity. Involved in corpus callosum development and negative regulation of neuron projection development. Predicted to be located in several cellular components, including cell surface; membrane raft; and perikaryon. Predicted to be active in external side of plasma membrane; extracellular matrix; and extracellular space. Is expressed in brain; cranial ganglion; and peripheral nervous system. Orthologous to human RTN4RL2 (reticulon 4 receptor like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cortex adult (RPKM 10.0), frontal lobe adult (RPKM 9.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.45 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (84701653..84718985, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (84871297..84888641, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that Versican/NgR2 signaling at the dermo-epidermal junction acts in vivo as a local suppressor of axonal plasticity to control proper density of epidermal sensory fiber innervation.
Title: Nogo receptor homolog NgR2 expressed in sensory DRG neurons controls epidermal innervation by interaction with Versican.
This study demonistrated that phosphorylation of CRMP-2 may be downstream of NgR1 activation and play a role in axonal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Title: Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.
Data show that genetic deletion of both receptors does not promote functional recovery during EAE and that NgR1 and NgR2-mediated signals play a minor role in the development of CNS inflammation.
Title: Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 T helper responses and CNS repair in experimental autoimmune encephalomyelitis.
These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin.
Title: Nogo receptor is involved in the adhesion of dendritic cells to myelin.
Rtn4r mutant mice exhibited greater social preference and a mild impairment in spatial cognition.
Title: Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice.
Sensory neurons deficient for both NgR proteins displayed only a moderate reduction of MAG-mediated inhibition of neurite growth.
Title: Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5.
predominantly expressed in the neurons of the embryonic and adult nervous systems
Title: Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495113

NoName (e-PCR)
- UniSTS:489567

Rtn4rl2 (e-PCR), detects polymorphism
- UniSTS:547537

Rtn4rl2 (e-PCR), detects polymorphism
- UniSTS:547538

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axon regeneration	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: reticulon-4 receptor-like 2

Names: nogo receptor-like 3; nogo-66 receptor homolog 1; nogo-66 receptor-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199223.1 → NP_954693.1 reticulon-4 receptor-like 2 precursor

See identical proteins and their annotated locations for NP_954693.1

Status: PROVISIONAL

Source sequence(s)

AY250220

Consensus CDS

CCDS16197.1

UniProtKB/Swiss-Prot

A2RTJ0, Q3UQ62, Q7M6Z0

UniProtKB/TrEMBL

A2ATS6

Related

ENSMUSP00000057725.6, ENSMUST00000054514.6

Conserved Domains (4) summary

cd00116
Location:103 → 261

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:62 → 83

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:156 → 215

LRR_8; Leucine rich repeat

cl15307
Location:261 → 311

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

84701653..84718985 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499594.5 → XP_006499657.1 reticulon-4 receptor-like 2 isoform X3

UniProtKB/TrEMBL

A2ATS6

Conserved Domains (4) summary

smart00082
Location:262 → 312

LRRCT; Leucine rich repeat C-terminal domain

PHA03247
Location:290 → 370

PHA03247; large tegument protein UL36; Provisional

sd00033
Location:63 → 84

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:157 → 216

LRR_8; Leucine rich repeat
XM_006499595.4 → XP_006499658.1 reticulon-4 receptor-like 2 isoform X4

UniProtKB/TrEMBL

A2ATS6

Conserved Domains (4) summary

PHA03247
Location:289 → 369

PHA03247; large tegument protein UL36; Provisional

sd00033
Location:62 → 83

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:156 → 215

LRR_8; Leucine rich repeat

cl15307
Location:261 → 311

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006499592.5 → XP_006499655.1 reticulon-4 receptor-like 2 isoform X1

UniProtKB/TrEMBL

A2ATS6

Conserved Domains (4) summary

smart00082
Location:321 → 371

LRRCT; Leucine rich repeat C-terminal domain

PHA03247
Location:349 → 429

PHA03247; large tegument protein UL36; Provisional

sd00033
Location:122 → 143

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:216 → 275

LRR_8; Leucine rich repeat
XM_006499593.4 → XP_006499656.1 reticulon-4 receptor-like 2 isoform X2

UniProtKB/TrEMBL

A2ATS6

Conserved Domains (4) summary

PHA03247
Location:327 → 407

PHA03247; large tegument protein UL36; Provisional

sd00033
Location:100 → 121

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:194 → 253

LRR_8; Leucine rich repeat

cl15307
Location:299 → 349

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006499596.4 → XP_006499659.1 reticulon-4 receptor-like 2 isoform X5

UniProtKB/TrEMBL

A2ATS6

Conserved Domains (4) summary

smart00082
Location:229 → 279

LRRCT; Leucine rich repeat C-terminal domain

PHA03247
Location:257 → 337

PHA03247; large tegument protein UL36; Provisional

sd00033
Location:30 → 51

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:124 → 183

LRR_8; Leucine rich repeat