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    Mmel1 membrane metallo-endopeptidase-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313755, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mmel1provided by RGD
    Official Full Name
    membrane metallo-endopeptidase-like 1provided by RGD
    Primary source
    RGD:1309299
    See related
    EnsemblRapid:ENSRNOG00000012593 AllianceGenome:RGD:1309299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NEP2; Mell1; NEPII
    Summary
    Enables metalloendopeptidase activity and zinc ion binding activity. Predicted to be involved in protein processing. Located in extracellular space. Orthologous to human MMEL1 (membrane metalloendopeptidase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 118.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mmel1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170713602..170744058)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165431278..165461716)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172273450..172303905)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479058 Neighboring gene tetratricopeptide repeat domain 34 Neighboring gene peroxiredoxin like 2B Neighboring gene TNF receptor superfamily member 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1. Facchinetti P, et al. Neuroscience, 2003. PMID 12710972
    2. Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin. Rose C, et al. Biochem J, 2002 May 1. PMID 11964170, Free PMC Article
    3. Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis. Ouimet T, et al. Biochem Biophys Res Commun, 2000 May 19. PMID 10814502
    4. The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity. Voisin S, et al. Biochem Biophys Res Commun, 2005 Sep 23. PMID 16081046
    5. A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2. Voisin S, et al. J Biol Chem, 2004 Oct 29. PMID 15294904

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin.
      Title: A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2.
    2. Modification of the structure of the C-terminal region will either impair substrate hydrolysis or completely abolish the secretion and enzymatic activity of the secreted isoform of rat NEP2.
      Title: The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    membrane metallo-endopeptidase-like 1
    Names
    NEP2(m)
    NL2
    mel transforming oncogene-like 1
    neprilysin 2
    neprilysin II
    NP_001101467.2
    XP_006239631.1
    XP_006239632.1
    XP_008762582.1
    XP_038966040.1
    XP_038966042.1
    XP_038966043.1
    XP_038966044.1
    XP_038966045.1
    XP_063143906.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107997.2 → NP_001101467.2  membrane metallo-endopeptidase-like 1

      Status: VALIDATED

      Source sequence(s)
      BC161870, JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0H2UHK7, A0A8L2QVP5
      Related
      ENSRNOP00000017957.4, ENSRNOT00000017957.8
      Conserved Domains (1) summary
      cd08662
      Location:106 → 772
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      170713602..170744058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110116.2 → XP_038966044.1  membrane metallo-endopeptidase-like 1 isoform X7

      Conserved Domains (1) summary
      pfam05649
      Location:107 → 419
      Peptidase_M13_N; Peptidase family M13

    2. XM_039110117.2 → XP_038966045.1  membrane metallo-endopeptidase-like 1 isoform X8

      Conserved Domains (1) summary
      pfam05649
      Location:107 → 421
      Peptidase_M13_N; Peptidase family M13

    3. XM_039110115.2 → XP_038966043.1  membrane metallo-endopeptidase-like 1 isoform X5

      Conserved Domains (1) summary
      pfam05649
      Location:107 → 506
      Peptidase_M13_N; Peptidase family M13

    4. XM_039110114.2 → XP_038966042.1  membrane metallo-endopeptidase-like 1 isoform X4

      Conserved Domains (1) summary
      pfam05649
      Location:107 → 506
      Peptidase_M13_N; Peptidase family M13

    5. XM_006239569.5 → XP_006239631.1  membrane metallo-endopeptidase-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QVP5
      Related
      ENSRNOP00000101044.1, ENSRNOT00000163920.1
      Conserved Domains (2) summary
      cd08662
      Location:106 → 751
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:98 → 753
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    6. XM_006239570.5 → XP_006239632.1  membrane metallo-endopeptidase-like 1 isoform X2

      UniProtKB/TrEMBL
      A6IUM6
      Related
      ENSRNOP00000062904.4, ENSRNOT00000064266.5
      Conserved Domains (2) summary
      cd08662
      Location:83 → 749
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:75 → 751
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    7. XM_008764360.4 → XP_008762582.1  membrane metallo-endopeptidase-like 1 isoform X3

      UniProtKB/TrEMBL
      A6IUM6
      Conserved Domains (1) summary
      cd08662
      Location:6 → 672
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

    8. XM_039110112.2 → XP_038966040.1  membrane metallo-endopeptidase-like 1 isoform X3

      UniProtKB/TrEMBL
      A6IUM6
      Conserved Domains (1) summary
      cd08662
      Location:6 → 672
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

    9. XM_063287836.1 → XP_063143906.1  membrane metallo-endopeptidase-like 1 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C1T0.1 GenPept UniProtKB/Swiss-Prot:P0C1T0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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