Eef1d eukaryotic translation elongation factor 1 delta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef1dprovided by MGI
Official Full Name: eukaryotic translation elongation factor 1 deltaprovided by MGI
Primary source: MGI:MGI:1913906
See related: Ensembl:ENSMUSG00000055762 AllianceGenome:MGI:1913906
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EF-1-delta
Summary: Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; guanyl-nucleotide exchange factor activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to heat; cellular response to ionizing radiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 124.2), liver E14 (RPKM 58.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 35.05 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (75766643..75781425, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (75894796..75909784, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the up-regulation of expression of TEF-1delta is a novel molecular mechanism responsible, at least in part, for cadmium carcinogenesis
Title: Up-regulation of expression of translation factors--a novel molecular mechanism for cadmium carcinogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129024 (e-PCR)
- UniSTS:212332

AA589397 (e-PCR)
- UniSTS:208766

RH125453 (e-PCR)
- UniSTS:162272

BF412712 (e-PCR)
- UniSTS:248289

NoName (e-PCR)
- UniSTS:236771

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation elongation factor 1 complex	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: elongation factor 1-delta

Names: eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285429.2 → NP_001272358.1 elongation factor 1-delta isoform b

See identical proteins and their annotated locations for NP_001272358.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.

Source sequence(s)

AC116520

Consensus CDS

CCDS27554.1

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

UniProtKB/TrEMBL

Q80T06

Conserved Domains (1) summary

pfam00736
Location:198 → 281

EF1_GNE; EF-1 guanine nucleotide exchange domain
NM_001285430.2 → NP_001272359.1 elongation factor 1-delta isoform b

See identical proteins and their annotated locations for NP_001272359.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.

Source sequence(s)

AC116520

Consensus CDS

CCDS27554.1

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

UniProtKB/TrEMBL

Q80T06

Related

ENSMUSP00000023235.7, ENSMUST00000023235.13

Conserved Domains (1) summary

pfam00736
Location:198 → 281

EF1_GNE; EF-1 guanine nucleotide exchange domain
NM_001285431.2 → NP_001272360.1 elongation factor 1-delta isoform c

See identical proteins and their annotated locations for NP_001272360.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.

Source sequence(s)

AC116520

Consensus CDS

CCDS70638.1

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

UniProtKB/TrEMBL

A0A0R4J1L2

Conserved Domains (1) summary

pfam00736
Location:174 → 257

EF1_GNE; EF-1 guanine nucleotide exchange domain
NM_001285432.2 → NP_001272361.1 elongation factor 1-delta isoform c

See identical proteins and their annotated locations for NP_001272361.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.

Source sequence(s)

AC116520

Consensus CDS

CCDS70638.1

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

UniProtKB/TrEMBL

A0A0R4J1L2

Related

ENSMUSP00000105599.3, ENSMUST00000109972.9

Conserved Domains (1) summary

pfam00736
Location:174 → 257

EF1_GNE; EF-1 guanine nucleotide exchange domain
NM_001285433.2 → NP_001272362.1 elongation factor 1-delta isoform c

See identical proteins and their annotated locations for NP_001272362.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.

Source sequence(s)

AC116520

Consensus CDS

CCDS70638.1

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

UniProtKB/TrEMBL

A0A0R4J1L2

Related

ENSMUSP00000112141.3, ENSMUST00000116440.9

Conserved Domains (1) summary

pfam00736
Location:174 → 257

EF1_GNE; EF-1 guanine nucleotide exchange domain
NM_001285434.2 → NP_001272363.1 elongation factor 1-delta isoform d

See identical proteins and their annotated locations for NP_001272363.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter, compared to isoform a.

Source sequence(s)

AC116520

Consensus CDS

CCDS70639.1

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

UniProtKB/TrEMBL

Q91VK2

Related

ENSMUSP00000087109.4, ENSMUST00000089680.10

Conserved Domains (1) summary

pfam00736
Location:193 → 276

EF1_GNE; EF-1 guanine nucleotide exchange domain
NM_001411966.1 → NP_001398895.1 elongation factor 1-delta isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.

Source sequence(s)

AC116520
NM_001411967.1 → NP_001398896.1 elongation factor 1-delta isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (10) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.

Source sequence(s)

AC116520
NM_001411968.1 → NP_001398897.1 elongation factor 1-delta isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (11) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.

Source sequence(s)

AC116520
NM_001411969.1 → NP_001398898.1 elongation factor 1-delta isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (12) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.

Source sequence(s)

AC116520

UniProtKB/TrEMBL

A0A0R4J1L2
NM_001411970.1 → NP_001398899.1 elongation factor 1-delta isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (13) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.

Source sequence(s)

AC116520

UniProtKB/TrEMBL

Q80T06
NM_023240.4 → NP_075729.2 elongation factor 1-delta isoform b

See identical proteins and their annotated locations for NP_075729.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.

Source sequence(s)

AC116520

Consensus CDS

CCDS27554.1

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

UniProtKB/TrEMBL

Q80T06

Related

ENSMUSP00000116360.2, ENSMUST00000154584.9

Conserved Domains (1) summary

pfam00736
Location:198 → 281

EF1_GNE; EF-1 guanine nucleotide exchange domain
NM_029663.3 → NP_083939.1 elongation factor 1-delta isoform a

See identical proteins and their annotated locations for NP_083939.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC116520

Consensus CDS

CCDS27553.1

UniProtKB/TrEMBL

A0A0R4J1E2, F6ZFU0

Related

ENSMUSP00000087110.6, ENSMUST00000089681.12

Conserved Domains (1) summary

pfam00736
Location:577 → 660

EF1_GNE; EF-1 guanine nucleotide exchange domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

75766643..75781425 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521267.4 → XP_006521330.1 elongation factor 1-delta isoform X1

See identical proteins and their annotated locations for XP_006521330.1

UniProtKB/TrEMBL

F6ZFU0

Conserved Domains (2) summary

pfam16471
Location:478 → 515

JIP_LZII; JNK-interacting protein leucine zipper II

pfam00736
Location:596 → 679

EF1_GNE; EF-1 guanine nucleotide exchange domain
XM_036159544.1 → XP_036015437.1 elongation factor 1-delta isoform X5

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

Conserved Domains (1) summary

pfam00736
Location:217 → 300

EF1_GNE; EF-1 guanine nucleotide exchange domain
XM_006521262.5 → XP_006521325.2 elongation factor 1-delta isoform X2

UniProtKB/TrEMBL

F6ZFU0

Conserved Domains (2) summary

pfam16471
Location:477 → 514

JIP_LZII; JNK-interacting protein leucine zipper II

pfam00736
Location:595 → 678

EF1_GNE; EF-1 guanine nucleotide exchange domain
XM_006521265.5 → XP_006521328.2 elongation factor 1-delta isoform X4

UniProtKB/TrEMBL

F6ZFU0

Related

ENSMUSP00000114753.2, ENSMUST00000137426.8

Conserved Domains (2) summary

pfam16471
Location:435 → 472

JIP_LZII; JNK-interacting protein leucine zipper II

pfam00736
Location:553 → 636

EF1_GNE; EF-1 guanine nucleotide exchange domain
XM_006521261.4 → XP_006521324.2 elongation factor 1-delta isoform X1

See identical proteins and their annotated locations for XP_006521324.2

UniProtKB/TrEMBL

F6ZFU0

Conserved Domains (2) summary

pfam16471
Location:478 → 515

JIP_LZII; JNK-interacting protein leucine zipper II

pfam00736
Location:596 → 679

EF1_GNE; EF-1 guanine nucleotide exchange domain
XM_006521264.5 → XP_006521327.2 elongation factor 1-delta isoform X3

UniProtKB/TrEMBL

F6ZFU0

Conserved Domains (2) summary

pfam16471
Location:458 → 495

JIP_LZII; JNK-interacting protein leucine zipper II

pfam00736
Location:576 → 659

EF1_GNE; EF-1 guanine nucleotide exchange domain
XM_036159543.1 → XP_036015436.1 elongation factor 1-delta isoform X5

UniProtKB/Swiss-Prot

P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5

Conserved Domains (1) summary

pfam00736
Location:217 → 300

EF1_GNE; EF-1 guanine nucleotide exchange domain
XM_006521266.5 → XP_006521329.2 elongation factor 1-delta isoform X1

See identical proteins and their annotated locations for XP_006521329.2

UniProtKB/TrEMBL

F6ZFU0

Conserved Domains (2) summary

pfam16471
Location:478 → 515

JIP_LZII; JNK-interacting protein leucine zipper II

pfam00736
Location:596 → 679

EF1_GNE; EF-1 guanine nucleotide exchange domain