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    Asb10 ankyrin repeat and SOCS box-containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499972, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Asb10provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 10provided by RGD
    Primary source
    RGD:1562922
    See related
    EnsemblRapid:ENSRNOG00000024885 AllianceGenome:RGD:1562922
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562922
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytoplasm and nucleus. Orthologous to human ASB10 (ankyrin repeat and SOCS box containing 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 160.1) and Heart (RPKM 94.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb10 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11522531..11531946)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10630318..10644270)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7158293..7167505)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily F member 2 Neighboring gene IQ motif containing with AAA domain 1 like Neighboring gene gastrulation brain homeobox 1 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134486542

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Variants in ASB10 are associated with open-angle glaucoma. Pasutto F, et al. Hum Mol Genet, 2012 Mar 15. PMID 22156576, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 10
    Names
    ankyrin repeat and SOCS box-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109216.2 → NP_001102686.1  ankyrin repeat and SOCS box protein 10

      See identical proteins and their annotated locations for NP_001102686.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168867
      UniProtKB/TrEMBL
      A0A8J8YAH4, B5DEZ7, F1LQJ8
      Related
      ENSRNOP00000037231.5, ENSRNOT00000037446.6
      Conserved Domains (6) summary
      smart00248
      Location:116 → 141
      ANK; ankyrin repeats
      cd00204
      Location:146 → 312
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03587
      Location:419 → 458
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      pfam12796
      Location:150 → 243
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:115 → 166
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:146 → 176
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11522531..11531946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235959.5 → XP_006236021.1  ankyrin repeat and SOCS box protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A096MJQ3
      Related
      ENSRNOP00000068220.1, ENSRNOT00000076953.4
      Conserved Domains (6) summary
      smart00248
      Location:103 → 128
      ANK; ankyrin repeats
      COG0666
      Location:64 → 286
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:133 → 299
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03587
      Location:406 → 445
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      pfam12796
      Location:253 → 343
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:133 → 163
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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